N-(4-broMobenzyl)-O-MethylhydroxylaMine

Base Information

• Chemical Name: N-(4-broMobenzyl)-O-MethylhydroxylaMine
• CAS No.: 916582-47-3
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 216.077
• Mol file: 916582-47-3.mol

Synonyms:N-(4-broMobenzyl)-O-MethylhydroxylaMine

Chemical Property of N-(4-broMobenzyl)-O-MethylhydroxylaMine

Chemical Property:

• PSA: 21.26000
• LogP: 2.49100

Purity/Quality:

99% ^*data from raw suppliers

N-(4-Bromobenzyl)-O-methylhydroxylamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-broMobenzyl)-O-MethylhydroxylaMine

There total 2 articles about N-(4-broMobenzyl)-O-MethylhydroxylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromobenzaldehyde O-methyloxime (33581-31-6) → O-methyl-N-(4-bromobenzyl)hydroxylamine (916582-47-3)

Guidance literature:

With sodium cyanoborohydride; acetyl chloride; In methanol; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201308905

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → O-methyl-N-(4-bromobenzyl)hydroxylamine (916582-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / ethanol / 1 h / 20 °C / Inert atmosphere

2: acetyl chloride; sodium cyanoborohydride / methanol / 1 h / 0 - 20 °C / Inert atmosphere

With pyridine; sodium cyanoborohydride; acetyl chloride; In methanol; ethanol;

DOI:10.1002/anie.201308905

upstream raw materials:

4-bromo-benzaldehyde

4-bromobenzaldehyde O-methyloxime

Refernces

• 1、 Nakajima, Minami,Oda, Yukiko,Wada, Takamasa,Minamikawa, Ryo,Shirokane, Kenji,Sato, Takaaki,Chida, Noritaka. "Chemoselective reductive nucleophilic addition to tertiary amides, secondary amides, and N-methoxyamides". . p. 17565 - 17571. Retrieved 2015/02/19.