2-phenyl-6-trifluoromethyl-pyrimidin-4-ol

Base Information

• Chemical Name: 2-phenyl-6-trifluoromethyl-pyrimidin-4-ol
• CAS No.: 158715-14-1
• Molecular Formula: C₁₁H₇F₃N₂O
• Molecular Weight: 240.185
• Hs Code.: 2933599590
• Mol file: 158715-14-1.mol

Synonyms:2-phenyl-6-trifluoromethyl-pyrimidin-4-ol;2-Phenyl-6-(trifluoromethyl)pyrimidin-4(1H)-one

Chemical Property of 2-phenyl-6-trifluoromethyl-pyrimidin-4-ol

Chemical Property:

• PSA: 46.01000
• LogP: 2.86800

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-2-phenyl-6-(trifluoromethyl)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-phenyl-6-trifluoromethyl-pyrimidin-4-ol

There total 3 articles about 2-phenyl-6-trifluoromethyl-pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzamidine monohydrochloride (1670-14-0) + 3,3,4,4,4-Pentafluoro-butyric acid ethyl ester (106693-04-3) → 2-Phenyl-6-trifluoromethyl-1H-pyrimidin-4-one (158715-14-1)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; at 60 ℃; for 9h;

DOI:10.1055/s-1996-4327

Reference yield: 83.0%

benzamidine monohydrochloride (1670-14-0) + ethyl 3-bromo-3,4,4,4-tetrafluorobutanoate (144850-59-9) → 2-Phenyl-6-trifluoromethyl-1H-pyrimidin-4-one (158715-14-1)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; at 60 ℃; for 9h;

DOI:10.1055/s-1996-4327

Reference yield: 82.0%

benzamidine monohydrochloride (1670-14-0) + 3,3-Dichloro-4,4,4-trifluoro-butyric acid ethyl ester → 2-Phenyl-6-trifluoromethyl-1H-pyrimidin-4-one (158715-14-1)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; at 60 ℃; for 10h;

DOI:10.1055/s-1996-4327

upstream raw materials:

benzamidine monohydrochloride

3,3,4,4,4-Pentafluoro-butyric acid ethyl ester

ethyl 3-bromo-3,4,4,4-tetrafluorobutanoate