2-BROMO-4-(4-METHOXY-PHENYL)-THIAZOLE

Base Information

• Chemical Name: 2-BROMO-4-(4-METHOXY-PHENYL)-THIAZOLE
• CAS No.: 99073-84-4
• Molecular Formula: C10H8BrNOS
• Molecular Weight: 270.14562
• Hs Code.: 2934100090
• Mol file: 99073-84-4.mol

Synonyms:2-BROMO-4-(4-METHOXY-PHENYL)-THIAZOLE

Chemical Property of 2-BROMO-4-(4-METHOXY-PHENYL)-THIAZOLE

Chemical Property:

• Vapor Pressure: 2.98E-05mmHg at 25°C
• Boiling Point: 367°C at 760 mmHg
• Flash Point: 175.7°C
• PSA: 50.36000
• Density: 1.521g/cm³
• LogP: 3.58120
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4-(4-methoxyphenyl)thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4-(4-METHOXY-PHENYL)-THIAZOLE

There total 2 articles about 2-BROMO-4-(4-METHOXY-PHENYL)-THIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

p-methoxyphenacyl thiocyanate (6097-26-3) → 2-bromo-4-(4-methoxyphenyl)thiazole (99073-84-4)

Guidance literature:

With hydrogen bromide; In diethyl ether; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2003.12.076

Reference yield:

2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-bromo-4-(4-methoxyphenyl)thiazole (99073-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / ethanol / 2 h / Heating

2: 62 percent / HBr / diethyl ether / 2 h / 20 °C

With hydrogen bromide; In diethyl ether; ethanol;

DOI:10.1016/j.bmcl.2003.12.076

upstream raw materials:

p-methoxyphenacyl thiocyanate

2-Bromo-4'-methoxyacetophenone

Refernces