3-Boc-6-aMino-3-azabicyclo[3.2.0]heptane

Base Information

• Chemical Name: 3-Boc-6-aMino-3-azabicyclo[3.2.0]heptane
• CAS No.: 1250884-66-2
• Molecular Formula: C11H20N2O2
• Molecular Weight: 212.2887
• Hs Code.: 2934999090
• Mol file: 1250884-66-2.mol

Synonyms:3-Boc-6-aMino-3-azabicyclo[3.2.0]heptane;tert-Butyl (1S,5R)-6-amino-3-azabicyclo[3.2.0]heptane-3-carboxylate;(1R,5S)-rel-tert-Butyl 6-amino-3-azabicyclo[3.2.0]heptane-3-carboxylate

Chemical Property of 3-Boc-6-aMino-3-azabicyclo[3.2.0]heptane

Chemical Property:

• Boiling Point: 294.8±23.0 °C(Predicted)
• PKA: 10.47±0.20(Predicted)
• Density: 1.111±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

3-Boc-6-amino-3-azabicyclo[3.2.0]heptane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Boc-6-aMino-3-azabicyclo[3.2.0]heptane

There total 4 articles about 3-Boc-6-aMino-3-azabicyclo[3.2.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

tert-butyl 6-oxo-3-azabicyclo[3.2.0]heptane-3-carboxylate (663172-80-3) → tert-butyl 6-amino-3-azabicyclo[3.2.0]heptane-3-carboxylate (1250884-66-2)

Guidance literature:

tert-butyl 6-oxo-3-azabicyclo[3.2.0]heptane-3-carboxylate; With hydroxylamine hydrochloride; sodium hydrogencarbonate; In methanol; at 20 ℃; for 16h;

With ammonia; hydrogen; In methanol; for 16h; under 30402 Torr;

DOI:10.1021/acs.joc.8b00077

Reference yield:

C13H17NO → tert-butyl 6-amino-3-azabicyclo[3.2.0]heptane-3-carboxylate (1250884-66-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 40 °C / 45603.1 Torr

2.1: dmap; triethylamine / dichloromethane / 12 h

2.2: 16 h / 0 - 20 °C

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 16 h / 20 °C

3.2: Raney nickel / 16 h / 30402 Torr

With dmap; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; triethylamine; In methanol; dichloromethane;

DOI:10.1021/acs.joc.8b00077

Reference yield:

3-azabicyclo[3.2.0]heptan-6-ol → tert-butyl 6-amino-3-azabicyclo[3.2.0]heptane-3-carboxylate (1250884-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 12 h

1.2: 16 h / 0 - 20 °C

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 16 h / 20 °C

2.2: Raney nickel / 16 h / 30402 Torr

With dmap; hydroxylamine hydrochloride; sodium hydrogencarbonate; triethylamine; In methanol; dichloromethane;

DOI:10.1021/acs.joc.8b00077

upstream raw materials:

tert-butyl 6-oxo-3-azabicyclo[3.2.0]heptane-3-carboxylate

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