3-a]pyrazine

Base Information

• Chemical Name: 3-a]pyrazine
• CAS No.: 1334135-57-7
• Molecular Formula: C₆H₅BrN₄O
• Molecular Weight: 229.036
• Hs Code.: 2933998090
• Mol file: 1334135-57-7.mol

Synonyms:3-a]pyrazine;5-broMo-8-Methoxy-[1;5-Bromo-8-methoxy-[1,2,4]triazolo[4,3-a]pyrazine;5-Bromo-8-methoxytriazolo[4,3-a]pyrazine

Chemical Property of 3-a]pyrazine

Chemical Property:

• PKA: -0.78±0.30(Predicted)
• PSA: 52.31000
• Density: 1.98±0.1 g/cm3(Predicted)
• LogP: 0.89540

Purity/Quality:

5-Bromo-8-methoxy-[1,2,4]triazolo[4,3-A]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-a]pyrazine

There total 2 articles about 3-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-3-hydrazinyl-2-methoxypyrazine (1334135-54-4) + orthoformic acid triethyl ester (122-51-0) → 5-bromo-8-methoxy-[1,2,4]triazolo[4,3-a]pyrazine (1334135-57-7)

Guidance literature:

at 130 ℃;

Reference yield:

3,5-dibromo-2-methoxypyrazine (1207853-31-3) → 5-bromo-8-methoxy-[1,2,4]triazolo[4,3-a]pyrazine (1334135-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 4 h / 80 °C

2: 130 °C

With hydrazine hydrate; In ethanol;

Reference yield:

5-bromo-8-methoxy-[1,2,4]triazolo[4,3-a]pyrazine (1334135-57-7) → 5-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-7-methyl-[1,2,4]triazolo[4,3-a]pyrazin-8-one

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; acetic acid / 4 h / 110 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

2.2: 5 h / 20 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / 1,4-dioxane; water / 2 h / 70 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; sodium hydride; acetic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

5-bromo-3-hydrazinyl-2-methoxypyrazine

orthoformic acid triethyl ester

3,5-dibromo-2-methoxypyrazine

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