4-bromo-3-[4-(chloromethyl)-3-fluorobenzoyl]-N,N-dimethyl-1H-Indole-1-carboxamide

Base Information

Chemical Name:4-bromo-3-[4-(chloromethyl)-3-fluorobenzoyl]-N,N-dimethyl-1H-Indole-1-carboxamide
CAS No.:200418-19-5
Molecular Formula:C19H15BrClFN2O2
Molecular Weight:437.6900032
Hs Code.:
DSSTox Substance ID:DTXSID201133492

Synonyms:200418-19-5;DTXSID201133492;AKOS015917804;4-bromo-3-[4-(chloromethyl)-3-fluorobenzoyl]-N,N-dimethyl-1H-Indole-1-carboxamide;FT-0686806

Suppliers and Price of 4-bromo-3-[4-(chloromethyl)-3-fluorobenzoyl]-N,N-dimethyl-1H-Indole-1-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 4-bromo-3-[4-(chloromethyl)-3-fluorobenzoyl]-N,N-dimethyl-1H-Indole-1-carboxamide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:562.32°C at 760 mmHg
Flash Point:293.88°C
Density:1.499g/cm³
XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:435.99895
Heavy Atom Count:26
Complexity:550

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C(=O)N1C=C(C2=C1C=CC=C2Br)C(=O)C3=CC(=C(C=C3)CCl)F

Technology Process of 4-bromo-3-[4-(chloromethyl)-3-fluorobenzoyl]-N,N-dimethyl-1H-Indole-1-carboxamide

There total 4 articles about 4-bromo-3-[4-(chloromethyl)-3-fluorobenzoyl]-N,N-dimethyl-1H-Indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 350-28-7
3-fluoro-4-methyl-benzoic acid

: 200418-19-5
4-Bromo-3-(4-chloromethyl-3-fluoro-benzoyl)-indole-1-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride, DMF / tetrahydrofuran / 0.5 h / Heating

2: sulfuryl chloride, benzoyl peroxide / benzene / 2.5 h / Heating

3: 1.) AlCl₃ / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT, 2.5 h

With aluminium trichloride; sulfuryl dichloride; Perbenzoic acid; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; benzene;
DOI:10.1021/jm970389+

Reference yield:

: 59189-97-8
3-fluoro-4-methylbenzoic acid chloride

: 200418-19-5
4-Bromo-3-(4-chloromethyl-3-fluoro-benzoyl)-indole-1-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuryl chloride, benzoyl peroxide / benzene / 2.5 h / Heating

2: 1.) AlCl₃ / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT, 2.5 h

With aluminium trichloride; sulfuryl dichloride; Perbenzoic acid; In benzene;
DOI:10.1021/jm970389+

Reference yield:

: 52488-36-5
4-bromo-1H-indole

: 200418-19-5
4-Bromo-3-(4-chloromethyl-3-fluoro-benzoyl)-indole-1-carboxylic acid dimethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) KOH / 1.) THF, RT, 15 min, 2.) THF, RT, 4 h

2: 1.) AlCl₃ / 1.) CH₂Cl₂, RT, 10 min, 2.) CH₂Cl₂, RT, 2.5 h

With potassium hydroxide; aluminium trichloride;
DOI:10.1021/jm970389+