4-Fluoro-3-methoxybenzylamine hydrochloride

Base Information

• Chemical Name: 4-Fluoro-3-methoxybenzylamine hydrochloride
• CAS No.: 869296-41-3
• Molecular Formula: C8H11ClFNO
• Molecular Weight: 191.633
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID30700748
• Mol file: 869296-41-3.mol

Synonyms:869296-41-3;4-FLUORO-3-METHOXYBENZYLAMINE HYDROCHLORIDE;(4-Fluoro-3-methoxyphenyl)methanamine hydrochloride;4-fluoro-3-methoxybenzylamine hcl;(4-fluoro-3-methoxyphenyl)methanamine;hydrochloride;SCHEMBL3646139;DTXSID30700748;NVBSKTURXJIMDG-UHFFFAOYSA-N;CK2401;MFCD04116343;AKOS015995470;AS-45899;CS-0210759;EN300-7400572;(4-Fluoro-3-methoxyphenyl)methanaminehydrochloride;A856542;A862986;4-fluoro-3-methoxybenzylamine hydrochloride, AldrichCPR;Z3235016255;1-(4-Fluoro-3-methoxyphenyl)methanamine--hydrogen chloride (1/1)

Chemical Property of 4-Fluoro-3-methoxybenzylamine hydrochloride

Chemical Property:

• PSA: 35.25000
• LogP: 2.79530
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 191.0513198
• Heavy Atom Count: 12
• Complexity: 121

Purity/Quality:

99% ^*data from raw suppliers

(4-Fluoro-3-methoxyphenyl)methanaminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)CN)F.Cl

Technology Process of 4-Fluoro-3-methoxybenzylamine hydrochloride

There total 1 articles about 4-Fluoro-3-methoxybenzylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H18FNO3 (943845-47-4) → 4-fluoro-3-methoxybenzylamine hydrochloride (869296-41-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1h;

Reference yield: 69.0%

4-fluoro-3-methoxybenzylamine hydrochloride (869296-41-3) + methyl 6-cyano-2-methylpyrimidine-4-carboxylate → 6-cyano-N-(4-fluoro-3-methoxybenzyl)-2-methylpyrimidine-4-carboxamide

Guidance literature:

4-fluoro-3-methoxybenzylamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In methanol; at 20 ℃; for 0.25h;

methyl 6-cyano-2-methylpyrimidine-4-carboxylate; In methanol; at 35 ℃; for 1h;

DOI:10.1021/acs.jmedchem.5b01434

Reference yield: 67.0%

ethyl 5,6-difluoro-4-oxo-3,4-dihydroquinazoline-2-carboxylate (869294-99-5) + 4-fluoro-3-methoxybenzylamine hydrochloride (869296-41-3) → 5,6-difluoro-N-{[4-fluoro-3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 80 ℃; for 6h;

upstream raw materials:

C₁₃H₁₈FNO₃

Downstream raw materials:

N-(4-fluoro-3-methoxy-benzyl)-4-(2-((trans-4-(2-hydroxy-2-methyl-propanoylamino)-cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methyl-picolinamide

N-(4-fluoro-3-methoxybenzyl)-5-(hydroxymethyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide

5-aminomethyl-2-fluorophenol hydrobromide

Refernces