5,6,7,8-tetrahydro-2-[4-(2-methoxyphenyl)-1-piperazinyl]-4(3H)-Quinazolinone

Base Information

Chemical Name:5,6,7,8-tetrahydro-2-[4-(2-methoxyphenyl)-1-piperazinyl]-4(3H)-Quinazolinone
CAS No.:925643-44-3
Molecular Formula:C₁₉H₂₄N₄O₂
Molecular Weight:340.425
Hs Code.:

Synonyms:5,6,7,8-tetrahydro-2-[4-(2-methoxyphenyl)-1-piperazinyl]-4(3H)-Quinazolinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,6,7,8-tetrahydro-2-[4-(2-methoxyphenyl)-1-piperazinyl]-4(3H)-Quinazolinone

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Technology Process of 5,6,7,8-tetrahydro-2-[4-(2-methoxyphenyl)-1-piperazinyl]-4(3H)-Quinazolinone

There total 2 articles about 5,6,7,8-tetrahydro-2-[4-(2-methoxyphenyl)-1-piperazinyl]-4(3H)-Quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 925643-44-3
2-[4-(2-methoxyphenyl)piperazin-1-yl]-5,6,7,8-tetrahydro-3H-quinazolin-4-one

Guidance literature:: In i-Amyl alcohol; at 150 ℃; for 2h; Microwave irradiation;

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 925643-44-3
2-[4-(2-methoxyphenyl)piperazin-1-yl]-5,6,7,8-tetrahydro-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / water / 20 h / 20 °C

2: toluene / 96 h / Reflux

With potassium carbonate; In water; toluene;
DOI:10.1021/acs.jmedchem.8b01888