2-Amino-N-butyl-3-phenylpropanamide hydrochloride

Base Information

• Chemical Name: 2-Amino-N-butyl-3-phenylpropanamide hydrochloride
• CAS No.: 1236254-97-9
• Molecular Formula: C₁₃H₂₀N₂O*ClH
• Molecular Weight: 256.776
• Hs Code.: 2924299090
• Mol file: 1236254-97-9.mol

Synonyms:2-Amino-N-butyl-3-phenylpropanamide hydrochloride

Chemical Property of 2-Amino-N-butyl-3-phenylpropanamide hydrochloride

Chemical Property:

• PSA: 55.12000
• LogP: 3.36590

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-N-butyl-3-phenylpropanamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-N-butyl-3-phenylpropanamide hydrochloride

There total 3 articles about 2-Amino-N-butyl-3-phenylpropanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-butylcarbamoyl-2-phenyl-ethyl-carbamic acid tert butyl ester (112670-44-7) → L-Phe-NHBu*HCl (1236254-97-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 22 ℃; for 0.5h;

DOI:10.1021/ja061166o

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → L-Phe-NHBu*HCl (1236254-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / HOBt*H₂O; EDC*HCl / CH₂Cl₂ / 4 h / 22 °C

2: 88 percent / aq. HCl / dioxane / 0.5 h / 22 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ja061166o

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → L-Phe-NHBu*HCl (1236254-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride; N-hydroxybenzotriazole / CH₂Cl₂ / 0.08 h / 22 °C

1.2: CH₂Cl₂ / 12 h

2.1: HCl / dioxane / 1 h / 0 - 22 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ja003747y

upstream raw materials:

1-butylcarbamoyl-2-phenyl-ethyl-carbamic acid tert butyl ester

N-tert-butoxycarbonyl-L-phenylalanine

Refernces

• 1、 Porter,Traverse,Hoveyda,Snapper. "Enantioselective synthesis of arylamines through Zr-catalyzed addition of dialkylzincs to imines. Reaction development by screening of parallel libraries [5]". . p. 984 - 985. Retrieved 2007/10/03.