6-TET

Base Information

• Chemical Name: 6-TET
• CAS No.: 155911-14-1
• Molecular Formula: C21H8Cl4O7
• Molecular Weight: 514.1
• Mol file: 155911-14-1.mol

Synonyms:6-TET;2',4,7,7'-Tetrachloro-3',6'-dihydroxy-3-oxo-spiro[isobenzofuran-1(3H),9'(9H)-xanthene]-6-carboxylic acid;6-Carboxy-2',4,7,7'-Tetrachlorofluorescein;Tetrachloro-6-carboxyfluorescein

Chemical Property of 6-TET

Chemical Property:

• Boiling Point: 788.9±60.0 °C(Predicted)
• PKA: 1.69±0.20(Predicted)
• PSA: 113.29000
• Density: 1.97±0.1 g/cm3(Predicted)
• LogP: 5.97760

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-TET

There total 1 articles about 6-TET which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3,6-dichloro-1,2,4-benzenetricarboxylic anhydride (81742-10-1) + 4-Chlororesorcinol (95-88-5) → 2',7'-dichloro-5(6)-carboxy-4,7-dichlorofluorescein (155911-14-1)

Guidance literature:

With methanesulfonic acid; at 50 - 110 ℃; for 28h; Inert atmosphere;

DOI:10.1007/s10895-014-1351-x

Reference yield:

2',7'-dichloro-5(6)-carboxy-4,7-dichlorofluorescein (155911-14-1) → 2′,7',4,7-tetrachloro-6-(3-carboxypropylaminocarbonyl)fluorescein

Guidance literature:

Multi-step reaction with 5 steps

1.1: 2 h / Reflux

1.2: -20 °C

2.1: hydrogenchloride / dichloromethane; water

3.1: pyridine / dichloromethane / 5 h / 20 °C

4.1: dichloromethane / 20 °C

5.1: ammonium hydroxide / dichloromethane / 2 h

5.2: pH 2

With pyridine; hydrogenchloride; ammonium hydroxide; In dichloromethane; water;

DOI:10.1007/s10895-014-1351-x

Reference yield:

2',7'-dichloro-5(6)-carboxy-4,7-dichlorofluorescein (155911-14-1) → 4-(2′,7′,4,7-tetrachlorofluorescein-6-carboxamido)-butanoic acid succinimidyl ester

Guidance literature:

Multi-step reaction with 6 steps

1.1: 2 h / Reflux

1.2: -20 °C

2.1: hydrogenchloride / dichloromethane; water

3.1: pyridine / dichloromethane / 5 h / 20 °C

4.1: dichloromethane / 20 °C

5.1: ammonium hydroxide / dichloromethane / 2 h

5.2: pH 2

6.1: pyridine / dichloromethane / 6 h / 20 °C

With pyridine; hydrogenchloride; ammonium hydroxide; In dichloromethane; water;

DOI:10.1007/s10895-014-1351-x

upstream raw materials:

3,6-dichloro-1,2,4-benzenetricarboxylic anhydride

4-Chlororesorcinol

Downstream raw materials:

2',7'-dichloro-6-carboxy-4,7-dichlorofluorescein dipivalate