6-(4-METHOXYPHENYL)-2-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE

Base Information

Chemical Name:6-(4-METHOXYPHENYL)-2-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE
CAS No.:946701-42-4
Molecular Formula:C14H12N2O2S
Molecular Weight:0
Hs Code.:
Mol file:946701-42-4.mol

Synonyms:6-(4-METHOXYPHENYL)-2-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(4-METHOXYPHENYL)-2-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE

Chemical Property:

Purity/Quality:

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Technology Process of 6-(4-METHOXYPHENYL)-2-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE

There total 3 articles about 6-(4-METHOXYPHENYL)-2-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 92754-10-4
6-(4-methoxyphenyl)-2-methylimidazo[2,1-b][1,3]thiazole

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 946701-42-4
6-(4-methoxyphenyl)-2-methylimidazo[2,1-b]thiazol-5-carbaldehyde

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; In chloroform; at 0 - 5 ℃;

6-(4-methoxyphenyl)-2-methylimidazo[2,1-b][1,3]thiazole; In chloroform; at 20 ℃; Reflux;

With water; Cooling with ice;
DOI:10.1002/cmdc.201000346

Reference yield:

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 946701-42-4
6-(4-methoxyphenyl)-2-methylimidazo[2,1-b]thiazol-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetone / Reflux

2.1: hydrogenchloride / water / 1 h / Reflux

3.1: trichlorophosphate / chloroform / 0 - 5 °C

3.2: 20 °C / Reflux

3.3: Cooling with ice

With hydrogenchloride; trichlorophosphate; In chloroform; water; acetone; 3.1: Vilsmeier formylation / 3.2: Vilsmeier formylation / 3.3: Vilsmeier formylation;
DOI:10.1002/cmdc.201000346

Reference yield:

: 92754-25-1
2-(2-Imino-5-methyl-thiazol-3-yl)-1-(4-methoxy-phenyl)-ethanone; hydrobromide

: 946701-42-4
6-(4-methoxyphenyl)-2-methylimidazo[2,1-b]thiazol-5-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 1 h / Reflux

2.1: trichlorophosphate / chloroform / 0 - 5 °C

2.2: 20 °C / Reflux

2.3: Cooling with ice

With hydrogenchloride; trichlorophosphate; In chloroform; water; 2.1: Vilsmeier formylation / 2.2: Vilsmeier formylation / 2.3: Vilsmeier formylation;
DOI:10.1002/cmdc.201000346