(R)-PhenoxybenzaMine Hydrochloride

Base Information

Chemical Name:(R)-PhenoxybenzaMine Hydrochloride
CAS No.:16053-59-1
Molecular Formula:C18H23Cl2NO
Molecular Weight:222
Hs Code.:
Mol file:16053-59-1.mol

Synonyms:(R)-PhenoxybenzaMine Hydrochloride;(+)-N-Benzyl-N-(2-chloroethyl)-1-phenoxyisopropylaMine Hydrochloride;(R)-N-(2-Chloroethyl)-N-(1-Methyl-2-phenoxyethyl)benzeneMethanaMine Hydrochloride;d-PhenoxybenzaMine Hydrochloride

Suppliers and Price of (R)-PhenoxybenzaMine Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-PhenoxybenzamineHydrochloride
50mg
$ 1230.00

Total 6 raw suppliers

Chemical Property of (R)-PhenoxybenzaMine Hydrochloride

Chemical Property:

Melting Point:124-126 °C
PSA：12.47000
LogP:4.99690

Purity/Quality:

98%Min ^*data from raw suppliers

(R)-PhenoxybenzamineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (R)-PhenoxybenzaMine Hydrochloride is used in the treatment of hypertension, it has a relatively slow onset and prolonged effect when compared to alternative α-blockers. An irreversible α-antagonist. Used in the treatment of hypertension, it has a relatively slow onset and prolonged effect when compared to alternative α-blockers.

Technology Process of (R)-PhenoxybenzaMine Hydrochloride

There total 9 articles about (R)-PhenoxybenzaMine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 34238-86-3
C₁₈H₂₃NO₂

: 16053-59-1,32378-29-3,5219-59-0
C₁₈H₂₂ClNO*ClH

Guidance literature:: C₁₈H₂₃NO₂; With hydrogenchloride; In benzene; at 0 ℃; for 0.25h;

With thionyl chloride; In benzene; for 8h; Reflux;
DOI:10.1016/j.tetasy.2010.11.011

Reference yield:

: 42060-32-2
N-benzyl-2-nitrobenzenesulfonamide

: 16053-59-1,32378-29-3,5219-59-0
C₁₈H₂₂ClNO*ClH

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: potassium carbonate; thiophenol / acetonitrile / 2 h

3.1: potassium carbonate / ethanol / 72 h / 110 °C

4.1: hydrogenchloride / benzene / 0.25 h / 0 °C

4.2: 8 h / Reflux

With hydrogenchloride; potassium carbonate; thiophenol; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; acetonitrile; benzene;
DOI:10.1016/j.tetasy.2010.11.011

Reference yield:

: (R)-N-benzyl-2-nitro-N-(1-phenoxypropan-2-yl)benzene-sulfonamide

: 16053-59-1,32378-29-3,5219-59-0
C₁₈H₂₂ClNO*ClH

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; thiophenol / acetonitrile / 2 h

2.1: potassium carbonate / ethanol / 72 h / 110 °C

3.1: hydrogenchloride / benzene / 0.25 h / 0 °C

3.2: 8 h / Reflux

With hydrogenchloride; potassium carbonate; thiophenol; In ethanol; acetonitrile; benzene;
DOI:10.1016/j.tetasy.2010.11.011