(S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid

Base Information

• Chemical Name: (S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid
• CAS No.: 911635-43-3
• Molecular Formula: C14H21F2NO5
• Molecular Weight: 321.3170464
• Mol file: 911635-43-3.mol

Synonyms:(S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid;3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid

Chemical Property of (S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid

There total 20 articles about (S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

→ 3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid (911635-43-3)

Guidance literature:

Reference yield:

3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid t-butyl ester (911635-42-2) + di-tert-butyl dicarbonate (24424-99-5) → 3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid (911635-43-3)

Guidance literature:

3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid t-butyl ester; With phosphoric acid; In dichloromethane; at 20 ℃; for 16h;

di-tert-butyl dicarbonate; With dihydrogen peroxide; In dichloromethane; water; for 3h; pH=7 - 9;

With hydrogenchloride; In water; pH=2 - 3;

Reference yield:

methyl 5-amino-4,4-difluoropentanoate hydrochloride (911634-74-7) + (3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid tert-butyl ester (153287-86-6) → 3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid (911635-43-3) + (3R)-3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxopiperidin-1-yl)butyric acid

Guidance literature:

(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid tert-butyl ester; With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; In dichloromethane; water; at 5 ℃;

methyl 5-amino-4,4-difluoropentanoate hydrochloride; In dichloromethane; water; at 20 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In dichloromethane; water;

upstream raw materials:

3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid t-butyl ester

di-tert-butyl dicarbonate

(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid tert-butyl ester

methyl 5-amino-4,4-difluoropentanoate hydrochloride