(S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid

Base Information

Chemical Name:(S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid
CAS No.:911635-43-3
Molecular Formula:C14H21F2NO5
Molecular Weight:321.3170464
Hs Code.:
Mol file:911635-43-3.mol

Synonyms:(S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid;3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid

Suppliers and Price of (S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 25 raw suppliers

Chemical Property of (S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Technology Process of (S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid

There total 20 articles about (S)-3-(tert-butoxycarbonyl)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 911635-43-3
3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid

Guidance literature:

Reference yield:

: 911635-42-2
3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid t-butyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 911635-43-3
3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid

Guidance literature:: 3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid t-butyl ester; With phosphoric acid; In dichloromethane; at 20 ℃; for 16h;

di-tert-butyl dicarbonate; With dihydrogen peroxide; In dichloromethane; water; for 3h; pH=7 - 9;

With hydrogenchloride; In water; pH=2 - 3;

Reference yield:

: 911634-74-7
methyl 5-amino-4,4-difluoropentanoate hydrochloride

: 153287-86-6
(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid tert-butyl ester

: 911635-43-3
3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid

: (3R)-3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxopiperidin-1-yl)butyric acid

Guidance literature:: (3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid tert-butyl ester; With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; In dichloromethane; water; at 5 ℃;

methyl 5-amino-4,4-difluoropentanoate hydrochloride; In dichloromethane; water; at 20 ℃; for 0.25h;

With sodium tris(acetoxy)borohydride; In dichloromethane; water;