3-fluorocyclobutanol

Base Information

• Chemical Name: 3-fluorocyclobutanol
• CAS No.: 1380170-67-1
• Molecular Formula: C₄H₇FO
• Molecular Weight: 90.0974
• Hs Code.: 2906190090
• Mol file: 1380170-67-1.mol

Synonyms:3-fluorocyclobutanol;3-fluorocyclobutan-1-ol

Chemical Property of 3-fluorocyclobutanol

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Fluorocyclobutanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluorocyclobutanol

There total 3 articles about 3-fluorocyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

trans-(3-fluorocyclobutyl) benzyl ether → trans-3-fluorocyclobutan-1-ol (1380170-67-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 25 ℃;

Reference yield: 60.0%

((3-fluorocyclobutoxy)methyl)benzene → 3-fluorocyclobutan-1-ol (1380170-67-1)

Guidance literature:

With methanol; palladium 10% on activated carbon; 10 wt% Pd(OH)2 on carbon; hydrogen; at 50 ℃; for 16h; under 2327.23 Torr;

Reference yield:

trans-3-(fluorocyclobutyl) benzyl ether (1262278-65-8) → trans-3-fluorocyclobutanol (1262278-60-3,1380170-67-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

DOI:10.1016/j.bmc.2012.11.049

upstream raw materials:

trans-3-(fluorocyclobutyl) benzyl ether

Refernces

• 1、 -. "PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES USEFUL FOR INHIBITING JANUS KINASE". Page/Page column 133. . Retrieved 2016/02/29.
• 2、 -. "RADIOLABELLING METHOD USING CYCLOALKYL GROUPS". Page/Page column 44-45. . Retrieved 2011/02/24.