2-METHOXY-3-METHYLPHENYLBORONIC ACID

Base Information

• Chemical Name: 2-METHOXY-3-METHYLPHENYLBORONIC ACID
• CAS No.: 909187-39-9
• Molecular Formula: C8H11BO3
• Molecular Weight: 165.985
• Hs Code.: 2931900090
• Mol file: 909187-39-9.mol

Synonyms:AKOS BRN-0647;2-METHOXY-3-METHYLPHENYLBORONIC ACID

Chemical Property of 2-METHOXY-3-METHYLPHENYLBORONIC ACID

Chemical Property:

• PSA: 49.69000
• LogP: -0.31660
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-3-methylphenylBoronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methoxy-3-methylphenyl Boronic Acid is used as a reactant in the synthesis of heterocyclic compounds as CGRP receptor antagonists.

Technology Process of 2-METHOXY-3-METHYLPHENYLBORONIC ACID

There total 1 articles about 2-METHOXY-3-METHYLPHENYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-2-methoxy-3-methylbenzene (52200-69-8) → 2-methoxy-3-methylphenylboronic acid (909187-39-9)

Guidance literature:

With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; at -70 - -20 ℃; for 0.5h;

Reference yield: 69.0%

tert-butyl 3-(7-chloro-8-fluoro-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate + 2-methoxy-3-methylphenylboronic acid (909187-39-9) → tert-butyl 3-(8-fluoro-2-((hexahydro-1H-pyrrolizin-7a-yl)methoxy)-7-(2-methoxy-3-methylphenyl)pyrido[4,3-d]pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:

With potassium phosphate; [(di(1-adamantyl)butylphosphine)-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate; In tetrahydrofuran; at 60 ℃; for 2h; Inert atmosphere;

Reference yield: 69.0%

4-bromo-2-nitro-1-pentyl-1H-imidazole + 2-methoxy-3-methylphenylboronic acid (909187-39-9) → 4-(2-methoxy-3-methylphenyl)-2-nitro-1-pentyl-1H-imidazole

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; at 85 ℃; for 8h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00023

upstream raw materials:

1-bromo-2-methoxy-3-methylbenzene

Downstream raw materials:

3-(2-Hydroxy-3-methyl-phenyl)-[1,1']binaphthalenyl-2,2'-diol

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