L-GLUTAMINE (5-13C)

Base Information

• Chemical Name: L-GLUTAMINE (5-13C)
• CAS No.: 159680-32-7
• Molecular Formula: C₅H₁₀N₂O₃
• Molecular Weight: 154.068
• Mol file: 159680-32-7.mol

Synonyms:L-GLUTAMINE (5-13C);(S)-2,5-DiaMino-5-oxopentanoic Acid-13C;2-AMinoglutaraMic Acid-13C;Acustasin-13C;Aesgen 14-13C;Cebrogen-13C;GluMin-13C;L-2-AMinoglutaraMidic Acid-13C

Chemical Property of L-GLUTAMINE (5-13C)

Chemical Property:

• Melting Point: 185 °C (dec. )(lit.)
• PSA: 107.40000
• LogP: 0.51380
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Aqueous Acid (Slightly), Water (Slightly, Sonicated)

Purity/Quality:

97% ^*data from raw suppliers

L-Glutamine-13C ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-GLUTAMINE (5-13C) is a labelled gluamine. L-GLUTAMINE (5-13C) is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-GLUTAMINE (5-13C) is very stable as a dry powder and as afrozen solution. In liquid media or stock solutions, however, L-GLUTAMINE (5-13C) degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-GLUTAMINE (5-13C) prior to use. L-Glutamine (5-13c, 99%) is a useful isotopic labeled intermediate for organic synthesis and other chemical processes.

Technology Process of L-GLUTAMINE (5-13C)

There total 3 articles about L-GLUTAMINE (5-13C) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(5-13C)-L-Glutamic acid (81202-00-8,95388-01-5) → (5-13C)-L-Glutamine (159680-32-7)

Guidance literature:

With ammonium chloride; adenosine 5'-triphosphate disodium salt; magnesium chloride; In water; at 38 ℃; for 24h; glutamine synthetase (GS, E_.C_. 6.3.1.2.), pH 7.1;

DOI:10.1002/recl.19941130706

Reference yield: 70.0%

C13(13)CH26N(15)NO5 → C4(13)CH10N(15)NO3 (159680-32-7,494783-18-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

(2S,3S,4R)-[3,4-(2)H2;1,2,3,4,5-(13)C5;2-(15)N]glutamic acid (554428-56-7,108395-12-6,1202063-54-4,206983-94-0,95388-01-5) → (2S,3S,4R)-[1,2,3,4,5-13C5;2,5-13N2;3,4-2H2]glutamine (554428-63-6,80143-57-3,184161-19-1,159680-32-7)

Guidance literature:

(2S,3S,4R)-[3,4-⁽²⁾H₂;1,2,3,4,5-⁽¹³⁾C₅;2-⁽¹⁵⁾N]glutamic acid; With sulfuric acid; In methanol; at -5 - 20 ℃; for 3h;

With carbon disulfide; ammonia; at 0 - 20 ℃; for 240h;

upstream raw materials:

(5-13C)-L-Glutamic acid

(2S,3S,4R)-[3,4-(2)H2;1,2,3,4,5-(13)C5;2-(15)N]glutamic acid

Refernces

• 1、 -. "HYPERPOLARIZED AND DEUTERIUM EXCHANGED HYPERPOLARIZED13C AND 15N-LABELED XANTHINE, ARGININE, GLUTAMINE, AND UREA PROBES". Paragraph 0100. . Retrieved 2019/04/11.