tert-butyl 6-fluoro-3-iodo-1H-indole-1-carboxylate

Base Information

Chemical Name:tert-butyl 6-fluoro-3-iodo-1H-indole-1-carboxylate
CAS No.:1627722-96-6
Molecular Formula:C13H13FINO2
Molecular Weight:361.1506932
Hs Code.:
Mol file:1627722-96-6.mol

Synonyms:tert-butyl 6-fluoro-3-iodoindole-1-carboxylate;1H-Indole-1-carboxylic acid, 6-fluoro-3-iodo-, 1,1-dimethylethyl ester

Suppliers and Price of tert-butyl 6-fluoro-3-iodo-1H-indole-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl6-fluoro-3-iodo-1H-indole-1-carboxylate 95+%
1g
$ 575.00

Chemenu
tert-Butyl6-fluoro-3-iodo-1H-indole-1-carboxylate 95%
1g
$ 538.00

Alichem
tert-Butyl6-fluoro-3-iodo-1H-indole-1-carboxylate
1g
$ 603.75

Total 7 raw suppliers

Chemical Property of tert-butyl 6-fluoro-3-iodo-1H-indole-1-carboxylate

Chemical Property:

Boiling Point:391.6±45.0 °C(Predicted)
Density:1.62±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl6-fluoro-3-iodo-1H-indole-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 6-fluoro-3-iodo-1H-indole-1-carboxylate

There total 2 articles about tert-butyl 6-fluoro-3-iodo-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 741265-04-3
6-fluoro-3-iodo-1H-indole

: 24424-99-5
di-tert-butyl dicarbonate

: 1627722-96-6
tert-butyl 6-fluoro-3-iodo-1H-indole-1-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.nucmedbio.2019.12.007

Reference yield:

: 399-51-9
6-fluoro-1H-indole

: 1627722-96-6
tert-butyl 6-fluoro-3-iodo-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 20 °C

2: triethylamine; dmap / dichloromethane / 20 °C

With dmap; iodine; triethylamine; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.nucmedbio.2019.12.007

Reference yield: 81.0%

: 1627722-96-6
tert-butyl 6-fluoro-3-iodo-1H-indole-1-carboxylate

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 1627721-59-8
tert-butyl 6-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In toluene; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.nucmedbio.2019.12.007