N-Des(diMethyl)-4-epi-tetracycline

Base Information

• Chemical Name: N-Des(diMethyl)-4-epi-tetracycline
• CAS No.: 53864-51-0
• Molecular Formula: C₂₀H₂₀N₂O₈
• Molecular Weight: 416.387
• Mol file: 53864-51-0.mol

Synonyms:N-Des(diMethyl)-4-epi-tetracycline;(4R,4aS,5aS,6S,12aS)-4-(AMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-2-naphthacenecarboxaMide-d6

Chemical Property of N-Des(diMethyl)-4-epi-tetracycline

Chemical Property:

• PSA: 205.39000
• LogP: 0.87610
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

N-Des(dimethyl)-4-epi-tetracycline(~70%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Des(diMethyl)-4-epi-tetracycline

There total 4 articles about N-Des(diMethyl)-4-epi-tetracycline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.1%

C20H19N3O8 → (4aS,5aS,6S,12aS)-4-Amino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide (1771-31-9,53864-51-0)

Guidance literature:

With sodium dithionite; In water; acetone; at 25 - 30 ℃; for 0.5h;

Reference yield:

TETRACYCLINE (60-54-8) → carbon dioxide (124-38-9,18923-20-1) + 4-Dedimethylaminotetracyclin (1771-31-9,53864-51-0) + C20H22N2O9 + C19H21NO8 + C19H21NO7 + C8H13NO3 + C12H14O3 + C19H18O7 + C11H12O3 + C8H12O4 + C22H26N2O9 + dedimethylaminotetracycline (110927-32-7,16639-33-1)

Guidance literature:

Kinetics; UV-irradiation;

DOI:10.1016/j.apcata.2016.06.025

Reference yield:

→ 4-Epi-N4.N4-dedimethyltetracyclin (53864-51-0)

Guidance literature:

4-Hydroxyimino-4-dedimethylamino-tetracyclin, NaSH, W./Acn.; neben geringen Mengen 4-Hydroxy-4-dedimethylamino-tetracyclin;

DOI:10.1139/v65-187

upstream raw materials:

TETRACYCLINE

Refernces

• 1、 Jinhai, Li,Han, Mengshu,Guo, Yang,Wang, Fei,Meng, Lingjun,Mao, Danjun,Ding, Shanshan,Sun, Cheng. "Hydrothermal synthesis of novel flower-like BiVO4/Bi2Ti2O7 with superior photocatalytic activity toward tetracycline removal". . p. 105 - 114. Retrieved 2016/07/11.