Lusutrombopag

Base Information

• Chemical Name: Lusutrombopag
• CAS No.: 1110766-97-6
• Molecular Formula: C29H32Cl2N2O5S
• Molecular Weight: 591.555
• Mol file: 1110766-97-6.mol

Synonyms:lusutrombopag;(S)-(E)-3-(2,6-dichloro-4-{4-[2-methyloxy-3-(1-hexyloxyethyl)phenyl]thiazol-2-ylcarbamoyl}phenyl)-2-methylacrylic acid;

Chemical Property of Lusutrombopag

Chemical Property:

• PKA: 4.33±0.21(Predicted)
• PSA: 125.99000
• Density: 1.299±0.06 g/cm3(Predicted)
• LogP: 8.59660

Purity/Quality:

99%(min) ^*data from raw suppliers

Lusutrombopag ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Lusutrombopag is a newly discovered thrombopoietin receptor agonist used in the treatment of patients with chronic ITP.

Technology Process of Lusutrombopag

There total 7 articles about Lusutrombopag which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S,E)-ethyl 3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylate (1110768-00-7) → (E)-3-(2,6-dichloro-4-((4-(3-((1S)-1-(hexyloxy)ethyl)-2-methoxyphenyl)-1,3-thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid (1110766-97-6)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 5h;

Reference yield: 80.0%

→ (E)-3-(2,6-dichloro-4-((4-(3-((1S)-1-(hexyloxy)ethyl)-2-methoxyphenyl)-1,3-thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid (1110766-97-6)

Guidance literature:

Reference yield:

1-[3-(2-amino-1,3-thiazol-4-yl)-2-methoxyphenyl]ethan-1-one → (E)-3-(2,6-dichloro-4-((4-(3-((1S)-1-(hexyloxy)ethyl)-2-methoxyphenyl)-1,3-thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid (1110766-97-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 5 - 20 °C

2.1: C₂₈H₄₅NO₄Zn^(1-)*K⁽¹⁺⁾ / tetrahydrofuran / 0.17 h / -5 °C

2.2: 6 h

3.1: potassium carbonate / tetrahydrofuran / 12 h / 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 60 °C

With C₂₈H₄₅NO₄Zn^(1-)*K⁽¹⁺⁾; water; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran;

upstream raw materials:

(S,E)-ethyl 3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylate

Refernces

• 1、 -. "PHARMACEUTICAL COMPOSITION CONTAINING OPTICALLY ACTIVE COMPOUND HAVING THROMBOPOIETIN RECEPTOR AGONIST ACTIVITY AND INTERMEDIATE THEREOF". Page/Page column 20-21. . Retrieved 2010/06/11.