[4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone

Base Information

Chemical Name:[4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone
CAS No.:1351758-81-0
Molecular Formula:C17H20ClN5O3
Molecular Weight:377.831
Hs Code.:
Mol file:1351758-81-0.mol

Synonyms:[4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone;HG-10-102-01;(4-((5-chloro-4- (methylamino)pyrimidin-2-yl)amino)- 3- methoxyphenyl)(morpholino)methano ne

Suppliers and Price of [4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
[4-[[5-Chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone
100mg
$ 6325.00

DC Chemicals
HG-10-102-01 >98%
1 g
$ 2600.00

DC Chemicals
HG-10-102-01 >98%
250 mg
$ 1300.00

Crysdot
HG-10-102-01 98+%
5mg
$ 190.00

Crysdot
HG-10-102-01 98+%
10mg
$ 265.00

Crysdot
HG-10-102-01 98+%
50mg
$ 975.00

Chemenu
HG-10-102-01 98%
50mg
$ 912.00

Chemenu
HG-10-102-01 98%
10mg
$ 248.00

Cayman Chemical
HG-10-102-01 ≥98%
10mg
$ 156.00

Cayman Chemical
HG-10-102-01 ≥98%
5mg
$ 98.00

Total 14 raw suppliers

Chemical Property of [4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone

Chemical Property:

Boiling Point:641.1±65.0 °C(Predicted)
PKA:4.60±0.10(Predicted)
PSA：88.61000
Density:1.381±0.06 g/cm3(Predicted)
LogP:2.48020
Solubility.:insoluble in H2O; ≥18.9 mg/mL in DMSO; ≥7.64 mg/mL in EtOH with ultrasonic

Purity/Quality:

99%, ^*data from raw suppliers

[4-[[5-Chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM). It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively). HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.
Uses [4-[[5-Chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone is an aminopyrimidine derivative as LRRK2 modulators used for the treatment of Parkinson's disease. [4-[[5-Chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone is an aminopyrimidine derivative as LRRK2 modulators used for the treatment of Parkinson''s disease.

Technology Process of [4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone

There total 5 articles about [4-[[5-Chloro-4-(MethylaMino)-2-pyriMidinyl]aMino]-3-Methoxyphenyl]-4-MorpholinylMethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (4-amino-3-methoxyphenyl)(morpholino)methanone

: 940927-35-5
2-chloro-5-chloro-N-methylpyrimidin-4-amine

: 1351758-81-0
[4-[[5-chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone

Guidance literature:: With trifluoroacetic acid; In iso-butanol; at 110 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ml300123a

Reference yield:

: 5081-36-7
3-methoxy-4-nitrobenzoic acid

: 1351758-81-0
[4-[[5-chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / toluene / 2 h / 120 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C

2.1: 10% Pd/C / methanol / 12 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / iso-butanol / 12 h / 110 °C / Inert atmosphere

With thionyl chloride; 10% Pd/C; trifluoroacetic acid; In methanol; toluene; iso-butanol;
DOI:10.1021/ml300123a

Reference yield:

: 2486-69-3
3-methoxy-4-aminobenzoic acid

: 1351758-81-0
[4-[[5-chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinylmethanone

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

2: trifluoroacetic acid / ethyl methyl ether / 18 h / 125 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethyl methyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm300452p