tert-butyl 4-(cyano(phenyl)Methylene)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(cyano(phenyl)Methylene)piperidine-1-carboxylate
• CAS No.: 1170054-42-8
• Molecular Formula: C18H22N2O2
• Molecular Weight: 298.385
• Mol file: 1170054-42-8.mol

Synonyms:tert-butyl 4-(cyano(phenyl)Methylene)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(cyano(phenyl)Methylene)piperidine-1-carboxylate

Chemical Property:

• PSA: 53.33000
• LogP: 3.93258

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(cyano(phenyl)methylene)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(cyano(phenyl)Methylene)piperidine-1-carboxylate

There total 2 articles about tert-butyl 4-(cyano(phenyl)Methylene)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + phenylacetonitrile (140-29-4) → tert-butyl 4-(cyano(phenyl)methylene)piperidine-1-carboxylate (1170054-42-8)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 20 - 60 ℃;

Reference yield:

tert-butyl 4-[cyano(phenyl)methyl]-4-hydroxypiperidine-1-carboxylate (1226997-62-1) → tert-butyl 4-(cyano(phenyl)methylene)piperidine-1-carboxylate (1170054-42-8)

Guidance literature:

With pyridine; thionyl chloride; for 0.166667h;

Reference yield:

tert-butyl 4-(cyano(phenyl)methylene)piperidine-1-carboxylate (1170054-42-8) → tert-butyl 4-(2-amino-1-phenylethyl)piperidine-1-carboxylate (1226997-63-2)

Guidance literature:

With ammonia; hydrogen; Raney nickel; In ethanol; for 24.5h; under 2482.38 Torr;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

phenylacetonitrile

tert-butyl 4-[cyano(phenyl)methyl]-4-hydroxypiperidine-1-carboxylate

Downstream raw materials:

phenyl(piperidin-4-ylidene)acetonitrile

tert-butyl 4-(2-amino-1-phenylethyl)piperidine-1-carboxylate