2-(2,4,6-TRIFLUOROPHENYL)ACETALDEHYDE

Base Information

• Chemical Name: 2-(2,4,6-TRIFLUOROPHENYL)ACETALDEHYDE
• CAS No.: 111991-19-6
• Molecular Formula: C8H5F3O
• Molecular Weight: 174.12
• Mol file: 111991-19-6.mol

Synonyms:2-(2,4,6-TRIFLUOROPHENYL)ACETALDEHYDE

Chemical Property of 2-(2,4,6-TRIFLUOROPHENYL)ACETALDEHYDE

Chemical Property:

• PSA: 17.07000
• LogP: 1.84530

Purity/Quality:

99% ^*data from raw suppliers

(2,4,6-Trifluorophenyl)acetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,4,6-TRIFLUOROPHENYL)ACETALDEHYDE

There total 3 articles about 2-(2,4,6-TRIFLUOROPHENYL)ACETALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3,5-trifluoro-2-[(E/Z)-2-methoxyvinyl]benzene (1201924-01-7) → (2,4,6-trifluorophenyl)acetaldehyde (111991-19-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.5h;

Reference yield:

2,4,6-trifluorobenzaldehyde (58551-83-0) → (2,4,6-trifluorophenyl)acetaldehyde (111991-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Inert atmosphere

1.2: 1.25 h / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 0.5 h

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

→ (2,4,6-trifluorophenyl)acetaldehyde (111991-19-6)

Guidance literature:

upstream raw materials:

2,4,6-trifluorobenzaldehyde

1,3,5-trifluoro-2-[(E/Z)-2-methoxyvinyl]benzene

Downstream raw materials:

2-amino-5-(2,4,6-trifluorophenyl)thiophene-3-carboxamide

Refernces

• 1、 -. "INHIBITORS OF JANUS KINASES". Page/Page column 75. . Retrieved 2009/01/23.