2-(2-hydroxyphenyl)-6-methylpyrimidin-4-ol

Base Information

• Chemical Name: 2-(2-hydroxyphenyl)-6-methylpyrimidin-4-ol
• CAS No.: 76467-22-6
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.213
• Mol file: 76467-22-6.mol

Synonyms:CHEMBRDG-BB 5339941;2-(2-HYDROXYPHENYL)-6-METHYL-4-PYRIMIDINOL;2-(2-hydroxyphenyl)-6-methyl-4-pyrimidinol(SALTDATA: FREE)

Chemical Property of 2-(2-hydroxyphenyl)-6-methylpyrimidin-4-ol

Chemical Property:

• Vapor Pressure: 0.000935mmHg at 25°C
• Boiling Point: 294.2°C at 760 mmHg
• Flash Point: 131.7°C
• Density: 1.31g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-hydroxyphenyl)-6-methylpyrimidin-4-ol

There total 3 articles about 2-(2-hydroxyphenyl)-6-methylpyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

hydroxybenzamidine (45744-18-1) + ethyl acetoacetate (141-97-9) → 2-(2-hydroxyphenyl)-6-methyl-4(3H)-pyrimidinone (76467-22-6)

Guidance literature:

In ethanol; Heating;

DOI:10.1021/jo00322a010

Reference yield: 26.0%

3-aminobutanoic acid ethyl ester (5303-65-1) + 4-chloro-2-methyl-2-methoxycarbonylmethyl-2H-1,3-benzoxazine (82507-98-0) → 2-(2-hydroxyphenyl)-6-methyl-4(3H)-pyrimidinone (76467-22-6) + ethyl (E)-crotonate (623-70-1)

Guidance literature:

at 170 - 180 ℃; for 3h;

DOI:10.1248/cpb.30.564

Reference yield:

2-(2-Hydroxyphenyl)-4-methyl-6-(2-hydroxybenzamido)pyrimidine (3605-06-9) → 2-(2-hydroxyphenyl)-6-methyl-4(3H)-pyrimidinone (76467-22-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; Yield given. Multistep reaction; 1.) 24 h, reflux, 2.) 48 h, reflux;

DOI:10.1021/jo00322a010

upstream raw materials:

3-aminobutanoic acid ethyl ester

4-chloro-2-methyl-2-methoxycarbonylmethyl-2H-1,3-benzoxazine

hydroxybenzamidine

ethyl acetoacetate