4-aMino-2-fluorobutanoic acid hydrochloride

Base Information

• Chemical Name: 4-aMino-2-fluorobutanoic acid hydrochloride
• CAS No.: 26437-22-9
• Molecular Formula: C₄H₈FNO₂*ClH
• Molecular Weight: 157.572
• Mol file: 26437-22-9.mol

Synonyms:4-aMino-2-fluorobutanoic acid hydrochloride

Chemical Property of 4-aMino-2-fluorobutanoic acid hydrochloride

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-2-fluorobutanoicacidhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-aMino-2-fluorobutanoic acid hydrochloride

There total 3 articles about 4-aMino-2-fluorobutanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (S)-4-(1,3-dioxoisoindolin-2-yl)-2-fluorobutanoate (130591-85-4) → (S)-4-amino-2-fluorobutanoic acid hydrochloride (26437-22-9)

Guidance literature:

With hydrogenchloride; water; for 16h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2009.03.072

Reference yield: 94.1%

methyl (R)-4-(1,3-dioxoisoindolin-2-yl)-2-fluorobutanoate (130591-89-8) → 4-amino-2(R)-fluorobutyric acid hydrochloride (26437-22-9)

Guidance literature:

With hydrogenchloride; In water; at 0 - 90 ℃; for 26h; Large scale;

Reference yield:

methyl 4-(1,3-dioxoisoindolin-2-yl)-2-fluorobutanoate → 2-fluoro-4-aminobutyric acid hydrochloride (26437-22-9)

Guidance literature:

With hydrogenchloride; water; at 90 ℃;

DOI:10.1111/cbdd.12762

upstream raw materials:

methyl (R)-4-(1,3-dioxoisoindolin-2-yl)-2-fluorobutanoate

methyl (S)-4-(1,3-dioxoisoindolin-2-yl)-2-fluorobutanoate