FMOC-D-MECHA-OH

Base Information

• Chemical Name: FMOC-D-MECHA-OH
• CAS No.: 1210834-55-1
• Molecular Formula: C₂₅H₂₉NO₄
• Molecular Weight: 407.51
• Mol file: 1210834-55-1.mol

Synonyms:N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-BETA-CYCLOHEXYL-D-ALANINE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-D-CYCLOHEXYLALANINE;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-D-CYCLOHEXYLALANINE;FMOC-D-MECHA-OH;FMOC-D-MEPHE(HEXAHYDRO)-OH;FMOC-N-ME-D-CHA-OH

Chemical Property of FMOC-D-MECHA-OH

Chemical Property:

• PSA: 66.84000
• LogP: 5.29090

Purity/Quality:

99.3% ^*data from raw suppliers

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-cyclohexylpropanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-D-MECHA-OH

There total 2 articles about FMOC-D-MECHA-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(4S)-3<<(9-fluorenylmethyl)oxy>carbonyl>-4-(cyclohexyl)methyl-5-oxooxazolidine → (S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-cyclohexylpropanoic acid (148983-03-3,1210834-55-1)

Guidance literature:

With triethylsilane; aluminum (III) chloride; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/acsmedchemlett.0c00154

Reference yield:

(S)-3-cyclohexyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid (135673-97-1) → (S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-cyclohexylpropanoic acid (148983-03-3,1210834-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / TsOH*H₂O / toluene / 1 h / Heating

2: 53 percent / Et₃SiH / CHCl₃ / 5 h / Ambient temperature

With triethylsilane; toluene-4-sulfonic acid; In chloroform; toluene;

DOI:10.1021/jm00047a020

upstream raw materials:

(S)-3-cyclohexyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid

Refernces

• 1、 Gmeiner, Peter,Hübner, Harald,Kaindl, Jonas,Kl?sel, Ilona,Schmidt, Maximilian F.,Weikert, Dorothee. "Discovery of Novel Nonpeptidic PAR2 Ligands". . p. 1316 - 1323. Retrieved 2020.