Boc-3-exo-aminobicyclo[2.2.1]-heptane-2-exo-carboxylic acid

Base Information

• Chemical Name: Boc-3-exo-aminobicyclo[2.2.1]-heptane-2-exo-carboxylic acid
• CAS No.: 76198-37-3
• Molecular Formula: C₁₃H₂₁NO₄
• Molecular Weight: 255.314
• Hs Code.: 2924299090
• Mol file: 76198-37-3.mol

Synonyms:3-((TERT-BUTOXYCARBONYL)AMINO)BICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID;3-[[(1,1-Dimethylethoxy)carbonyl]amino]bicyclo[2.2.1]heptane-2-carboxylic acid;Bicyclo[2.2.1]heptane-2-carboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-

Chemical Property of Boc-3-exo-aminobicyclo[2.2.1]-heptane-2-exo-carboxylic acid

Chemical Property:

• Boiling Point: 414.1±24.0 °C(Predicted)
• PKA: 4.54±0.40(Predicted)
• PSA: 75.63000
• Density: 1.19±0.1 g/cm3(Predicted)
• LogP: 2.40130

Purity/Quality:

98%min ^*data from raw suppliers

Boc-3-exo-aminobicyclo[2.2.1]-heptane-2-exo-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Boc-3-exo-aminobicyclo[2.2.1]-heptane-2-exo-carboxylic acid

There total 3 articles about Boc-3-exo-aminobicyclo[2.2.1]-heptane-2-exo-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(1S,2R,3R,4R,3'S)-[N-(4-carboxyphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] 3-tert-butoxycarbonylaminobicyclo[2.2.1]heptane-2-carboxylate → (1S,2R,3R,4R)-3-tert-butoxycarbonylaminobicyclo[2.2.1]heptane-2-carboxylic acid (1212373-01-7,1217790-09-4,76198-37-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 5h;

DOI:10.1016/j.tetasy.2007.10.001

Reference yield:

3-aminonorbornane-2-carboxylic acid (202280-02-2,202280-03-3) + 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) → 3-(N-tert-butoxycarbonylamino)norbornane-2-carboxylic acid (1212373-01-7,1217790-09-4,76198-37-3)

Guidance literature:

With triethylamine; In 1,4-dioxane; water;

Reference yield:

(1R,2S,3S,4S,3'R)-[N-(4-carboxyphenyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl] 3-tert-butoxycarbonylaminobicyclo[2.2.1]heptane-2-carboxylate → (1R,2S,3S,4S)-3-tert-butoxycarbonylaminobicyclo[2.2.1]heptane-2-carboxylic acid (1212373-01-7,1217790-09-4,76198-37-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1016/j.tetasy.2007.10.001

upstream raw materials:

3-aminonorbornane-2-carboxylic acid

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

Refernces

• 1、 -. "5-Fluorouracil derivatives, and their pharmaceutical compositions". . . Retrieved 2008/06/13.