6-Amino-4-[(3-methylphenyl)amino]quinazoline

Base Information

Chemical Name:6-Amino-4-[(3-methylphenyl)amino]quinazoline
CAS No.:153436-70-5
Molecular Formula:C₁₅H₁₄N₄
Molecular Weight:250.303
Hs Code.:
UNII:6G9S589MJE
ChEMBL ID:CHEMBL336113
Nikkaji Number:J1.505.930C
Mol file:153436-70-5.mol

Synonyms:6-amino-4-[(3-methylphenyl)amino]quinazoline;153436-70-5;CHEMBL336113;N4-(3-methylphenyl)-4,6-quinazolinediamine;4-N-(3-methylphenyl)quinazoline-4,6-diamine;Anilinoquinazoline, 4a;SMA52;SCHEMBL159209;6G9S589MJE;NFBCSWGEYDCCDW-UHFFFAOYSA-N;BDBM50133384;AKOS013914431;N4-(m-Tolyl)quinazoline-4,6-diamine;N*4*-m-Tolyl-quinazoline-4,6-diamine;6-amino-4-(3'-methylanilino)quinazoline;PD128822;6-amino-4-(3-methylphenylamino)-quinazoline;6-amino-4[(3-methylphenyl)amino]quinazoline;FT-0765557;N4-(3-Methylphenyl)quinazoline-4,6-diamine;6-amino-4[(3-methylphenyl)amino]-quinazoline;4,6-Quinazolinediamine, N4-(3-methylphenyl)-

Suppliers and Price of 6-Amino-4-[(3-methylphenyl)amino]quinazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-Amino-4-[(3-methylphenyl)amino]quinazoline

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:250.121846464
Heavy Atom Count:19
Complexity:296

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC=C1)NC2=NC=NC3=C2C=C(C=C3)N

Technology Process of 6-Amino-4-[(3-methylphenyl)amino]quinazoline

There total 8 articles about 6-Amino-4-[(3-methylphenyl)amino]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 146885-20-3
4-(3'-methylanilino)-6-nitroquinazoline

: 153436-70-5
6-amino-4-[(3-methylphenyl)amino]quinazoline

Guidance literature:: With hydrogen; nickel; In tetrahydrofuran; methanol; at 25 ℃; for 3.5h; under 2715.03 Torr;
DOI:10.1021/jm9806603

Reference yield: 43.0%

: 153436-70-5
6-amino-4-[(3-methylphenyl)amino]quinazoline

Guidance literature:

Reference yield:

: 17420-30-3
5-nitroanthranilonitrile

: 153436-70-5
6-amino-4-[(3-methylphenyl)amino]quinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂SO₄ / 0.5 h / Heating

2: PCl₅ / 2.5 h / 160 °C

3: 4.4 g / propan-2-ol / 60 °C

4: 55 percent / H₂ / Pd/C / methanol / 1 h / 20 °C / 1500.12 Torr

With phosphorus pentachloride; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; isopropyl alcohol;
DOI:10.1021/jm0600390