9H-Purin-6-amine, 9-(1-propenyl)-

Base Information

Chemical Name:9H-Purin-6-amine, 9-(1-propenyl)-
CAS No.:4121-40-8
Molecular Formula:C8H9N5
Molecular Weight:175.193
Hs Code.:
DSSTox Substance ID:DTXSID501296376
Mol file:4121-40-8.mol

Synonyms:9H-Purin-6-amine, 9-(1-propenyl)-;(Z)-Mutagenic Impurity of Tenofovir Disoproxil;Mutagenic Impurity of Tenofovir Disoproxil;Tenofovir Impurity 2;SCHEMBL8540979;DTXSID501296376;AKOS028110083;s11146;9-(1-propen-1-yl)-9H-Purin-6-amine

Suppliers and Price of 9H-Purin-6-amine, 9-(1-propenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
9-Propenyladenine
10mg
$ 403.00

Usbiological
9-Propenyladenine
1mg
$ 355.00

TRC
9-Propenyladenine
50mg
$ 330.00

AccelPharmtech
9-(1-propen-1-yl)-9H-Purin-6-amine 95%
10G
$ 2580.00

AccelPharmtech
9-(1-propen-1-yl)-9H-Purin-6-amine 95%
1G
$ 740.00

Total 22 raw suppliers

Chemical Property of 9H-Purin-6-amine, 9-(1-propenyl)-

Chemical Property:

Melting Point:197℃
Boiling Point:415.6±48.0 °C(Predicted)
PKA:4.08±0.10(Predicted)
PSA：69.62000
Density:1.39±0.1 g/cm3(Predicted)
LogP:1.48030
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:175.08579531
Heavy Atom Count:13
Complexity:205

Purity/Quality:

99%, ^*data from raw suppliers

9-Propenyladenine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC=CN1C=NC2=C(N=CN=C21)N
Uses 9-Propenyladenine is an N-substituted purine and an impurity of Tenofovir (T018500). Tenofovir Disoproxil Related Compound B ((E)-9-(Prop-1-enyl)-9H-purin-6-amine). 9-Propenyladenine (Tenofovir Disoproxil USP Related Compound B) is an N-substituted purine and an impurity of Tenofovir (T018500). Tenofovir Disoproxil Related Compound B ((E)-9-(Prop-1-enyl)-9H-purin-6-amine).

Technology Process of 9H-Purin-6-amine, 9-(1-propenyl)-

There total 4 articles about 9H-Purin-6-amine, 9-(1-propenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

: 9-formyladenine

: 1530-32-1
ethyltriphenylphosphonium bromide

: 4121-40-8,1464851-21-5
9-propenyladenine

Guidance literature:: With lithium ethoxide; In tetrahydrofuran; ethanol; at 20 ℃; for 0.5h; Concentration; Temperature;

Reference yield:

: 6034-68-0
N⁶-acetyladenine

: 4121-40-8,1464851-21-5
9-propenyladenine

Guidance literature:: Multi-step reaction with 3 steps

1: formic acid ethyl ester / 7 h / Reflux

2: sodium hydroxide / water / 2 h / 70 °C

3: lithium ethoxide / tetrahydrofuran; ethanol / 0.5 h / 20 °C

With lithium ethoxide; sodium hydroxide; formic acid ethyl ester; In tetrahydrofuran; ethanol; water; 3: |Wittig Olefination;

Reference yield:

: C₈H₇N₅O₂

: 4121-40-8,1464851-21-5
9-propenyladenine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water / 2 h / 70 °C

2: lithium ethoxide / tetrahydrofuran; ethanol / 0.5 h / 20 °C

With lithium ethoxide; sodium hydroxide; In tetrahydrofuran; ethanol; water; 2: |Wittig Olefination;