1-(2,1,3-Benzothiadiazol-5-yl)-2-(6-Methyl-2-pyridinyl)-1,2-ethanedione

Base Information

• Chemical Name: 1-(2,1,3-Benzothiadiazol-5-yl)-2-(6-Methyl-2-pyridinyl)-1,2-ethanedione
• CAS No.: 364050-15-7
• Molecular Formula: C14H9N3O2S
• Molecular Weight: 283.30516
• Mol file: 364050-15-7.mol

Synonyms:1-(2,1,3-Benzothiadiazol-5-yl)-2-(6-Methyl-2-pyridinyl)-1,2-ethanedione

Chemical Property of 1-(2,1,3-Benzothiadiazol-5-yl)-2-(6-Methyl-2-pyridinyl)-1,2-ethanedione

Chemical Property:

• PSA: 101.05000
• LogP: 2.46030

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,1,3-Benzothiadiazol-5-yl)-2-(6-Methyl-2-pyridinyl)-1,2-ethanedione

There total 4 articles about 1-(2,1,3-Benzothiadiazol-5-yl)-2-(6-Methyl-2-pyridinyl)-1,2-ethanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(benzo[c][1,2,5]thiadiazol-5-yl)-1-(6-methylpyridin-2-yl)ethanone → 1-(benzo[c] [1,2,5]thiadiazol-5-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione (364050-15-7)

Guidance literature:

With hydrogen bromide; In water; dimethyl sulfoxide; at 100 ℃; for 1.5h;

DOI:10.1016/j.bmcl.2019.07.015

Reference yield:

1-Benzo[1,2,5]thiadiazol-5-yl-2-(6-methyl-pyridin-2-yl)-ethanone (364050-23-7) → 1-(benzo[c] [1,2,5]thiadiazol-5-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione (364050-15-7)

Guidance literature:

With hydrogen bromide; In water; dimethyl sulfoxide;

Reference yield:

benzo[c][1,2,5]thiadiazole-5-carbaldehyde (71605-72-6) → 1-(benzo[c] [1,2,5]thiadiazol-5-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione (364050-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / tetrahydrofuran; isopropyl alcohol / 7 h / 20 °C

2: hydrogen bromide / dimethyl sulfoxide; water / 1.5 h / 100 °C

With hydrogen bromide; caesium carbonate; In tetrahydrofuran; water; dimethyl sulfoxide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2019.07.015

upstream raw materials:

1-Benzo[1,2,5]thiadiazol-5-yl-2-(6-methyl-pyridin-2-yl)-ethanone

benzo[c][1,2,5]thiadiazole-5-carbaldehyde

diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate

Refernces

• 1、 -. "Triarylimidazole derivatives as cytokine inhibitors". . . Retrieved 2008/06/13.