3-Pyridinecarboxylic acid, 4-aMino-6-chloro-

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid, 4-aMino-6-chloro-
• CAS No.: 1060811-65-5
• Molecular Formula: C₆H₅ClN₂O₂
• Molecular Weight: 172.571
• Hs Code.: 2933399090
• Mol file: 1060811-65-5.mol

Synonyms:3-Pyridinecarboxylic acid, 4-aMino-6-chloro-;4-AMino-6-chloronicotinic acid;4-amino-6-chloropyridine-3-carboxylic acid

Chemical Property of 3-Pyridinecarboxylic acid, 4-aMino-6-chloro-

Chemical Property:

• Boiling Point: 433.9±45.0 °C(Predicted)
• PKA: 2.71±0.10(Predicted)
• PSA: 76.21000
• Density: 1.577±0.06 g/cm3(Predicted)
• LogP: 1.59660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-6-chloronicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 4-aMino-6-chloro-

There total 1 articles about 3-Pyridinecarboxylic acid, 4-aMino-6-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.1%

methyl 4-amino-6-chloro-pyridine-3-carboxylate (1256785-40-6) → 4-amino-6-chloropyridine-3-carboxylic acid (1060811-65-5)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃; for 12h;

Reference yield: 76.0%

4-amino-6-chloropyridine-3-carboxylic acid (1060811-65-5) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 4-amino-6-chloro-pyridine-3-carboxylate (1256785-40-6)

Guidance literature:

With methanol; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/acsmedchemlett.0c00267

Reference yield: 20.0%

4-amino-6-chloropyridine-3-carboxylic acid (1060811-65-5) + p-tert-butyl benzoyl chloride (1710-98-1) → 4-(4-(tert-butyl)benzamido)-6-chloronicotinic acid

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 18h;

DOI:10.1021/acsmedchemlett.0c00267

upstream raw materials:

methyl 4-amino-6-chloro-pyridine-3-carboxylate

Downstream raw materials:

methyl 4-amino-6-chloro-pyridine-3-carboxylate

Refernces

• 1、 -. "KRAS G12C INHIBITORS". Paragraph 0752. . Retrieved 2020/07/25.