4-Hydrazinyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester hydrochloride

Base Information

• Chemical Name: 4-Hydrazinyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester hydrochloride
• CAS No.: 1258001-18-1
• Molecular Formula: C10H21N3O2.HCl
• Molecular Weight: 251.757
• Mol file: 1258001-18-1.mol

Synonyms:4-Hydrazinyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester hydrochloride;tert-Butyl 4-hydrazinopiperidine-1-carboxylate hydrochloride;t-Butyl 4-hydrazinylpiperidine-1-carboxylate HCl

Chemical Property of 4-Hydrazinyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester hydrochloride

Chemical Property:

• PSA: 67.59000
• LogP: 2.68030

Purity/Quality:

99% ^*data from raw suppliers

t-Butyl4-Hydrazinylpiperidine-1-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydrazinyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester hydrochloride

There total 1 articles about 4-Hydrazinyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → di-tert-butyl-4,4'-hydrazine-1,2-diyldipiperidine-1-carboxylate (1258001-19-2) + tert-butyl 4-hydrazinylpiperidine-1-carboxylate hydrochloride (1258001-18-1)

Guidance literature:

With hydrazine hydrochloride; hydrogen; platinum on carbon; In methanol; water; for 15h; under 45603.1 Torr; Inert atmosphere; Sealed autoclave;

Reference yield: 68.0%

tert-butyl 4-hydrazinylpiperidine-1-carboxylate hydrochloride (1258001-18-1) + methyl 3-(4-methanesulfonylphenyl)-2-methyl-3-oxopropanoate → tert-butyl 4-[5-hydroxy-3-(4-methanesulfonylphenyl)-4-methyl-1H-pyrazol-1-yl]piperidine-1-carboxylate

Guidance literature:

With triethylamine; In ethanol; at 80 ℃; for 19h; Sealed tube;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

Refernces

• 1、 -. "L- ( PIPERIDIN-4-YL) -PYRAZOLE DERIVATIVES AS GPR 119 MODULATORS". Page/Page column 54. . Retrieved 2010/12/29.