2-CHLORO-4-(3-METHYLPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

Base Information

Chemical Name:2-CHLORO-4-(3-METHYLPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER
CAS No.:74476-61-2
Molecular Formula:C13H12ClNO2S
Molecular Weight:281.763
Hs Code.:
Mol file:74476-61-2.mol

Synonyms:2-CHLORO-4-(3-METHYLPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

Suppliers and Price of 2-CHLORO-4-(3-METHYLPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-CHLORO-4-(3-METHYLPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

Chemical Property:

Boiling Point:135 - 140 °C
PSA：67.43000
LogP:3.94860

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-4-(3-METHYLPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

There total 4 articles about 2-CHLORO-4-(3-METHYLPHENYL)-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68301-48-4
2-amino-4-m-tolyl-thiazole-5-carboxylic acid ethyl ester

: 74476-61-2
ethyl 2-chloro-4-m-tolyl-5-thiazolecarboxylate

Guidance literature:: With hydrogenchloride; phosphoric acid; nitric acid; sodium nitrite; Yield given. Multistep reaction; 1.) -5 to 0 deg C, 10 min, 2.) 30 min;;

Reference yield:

: 74476-60-1
2-Chloro-3-oxo-3-m-tolyl-propionic acid ethyl ester

: 74476-61-2
ethyl 2-chloro-4-m-tolyl-5-thiazolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / ethanol / 16 h / Heating

2: 1.) 85percent H₃PO₄, 70percent HNO₃, NaNO₂, 2.) aq. HCl, CuCl; / 1.) -5 to 0 deg C, 10 min, 2.) 30 min;

With hydrogenchloride; phosphoric acid; nitric acid; sodium nitrite; In ethanol;

Reference yield:

: 1711-06-4
3-Methylbenzoyl chloride

: 74476-61-2
ethyl 2-chloro-4-m-tolyl-5-thiazolecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 17 percent / 1.) aq. NaOH, 2.) aq. NH₃, NH₄Cl; / 1.) benzene, 35 deg C, 3 h, 2.) 40-50 deg C, 3 h;

2: SO₂Cl₂

3: 61 percent / ethanol / 16 h / Heating

4: 1.) 85percent H₃PO₄, 70percent HNO₃, NaNO₂, 2.) aq. HCl, CuCl; / 1.) -5 to 0 deg C, 10 min, 2.) 30 min;

With hydrogenchloride; ammonium hydroxide; sodium hydroxide; sulfuryl dichloride; phosphoric acid; nitric acid; ammonium chloride; sodium nitrite; In ethanol;