(1R)-1-(furan-2-yl)ethan-1-amine

Base Information

• Chemical Name: (1R)-1-(furan-2-yl)ethan-1-amine
• CAS No.: 132523-44-5
• Molecular Formula: C6H9NO
• Molecular Weight: 111.144
• DSSTox Substance ID: DTXSID90426952
• Nikkaji Number: J64.874D
• Wikidata: Q82239731
• Mol file: 132523-44-5.mol

Synonyms:132523-44-5;(1R)-1-(furan-2-yl)ethan-1-amine;(R)-1-(furan-2-yl)ethanamine;(1R)-1-(FURAN-2-YL)ETHANAMINE;(R)-1-(Furan-2-yl)ethan-1-amine;(R)-ALPHA-METHYLFURFURYLAMINE;(R)-|A-Methylfurfurylamine;SCHEMBL12262635;DTXSID90426952;MFCD09256705;AKOS017463728;[R,(+)]-alpha-Methyl-2-furanmethanamine;CS-0444570;EN300-89268;Y12106

Chemical Property of (1R)-1-(furan-2-yl)ethan-1-amine

Chemical Property:

• Boiling Point: 120.5±15.0 °C(Predicted)
• PKA: 9.58±0.29(Predicted)
• PSA: 39.16000
• Density: 1.015±0.06 g/cm3(Predicted)
• LogP: 1.99960
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 111.068413911
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

98%min ^*data from raw suppliers

(R)-α-Methylfurfurylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CO1)N
• Isomeric SMILES: C[C@H](C1=CC=CO1)N
• Uses: (R)-α-MethylfurfurylaMine can be used in the enantioselective synthesis of furanyl amines and amino acids.

Technology Process of (1R)-1-(furan-2-yl)ethan-1-amine

There total 17 articles about (1R)-1-(furan-2-yl)ethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C10H15NO2S (873695-49-9) → (R)-1-(furan-2-yl)ethanamine (132523-44-5)

Guidance literature:

C₁₀H₁₅NO₂S; With [RhCl₂(p-cymene)]2; potassium tert-butylate; 2-Amino-2-methyl-1-propanol; isopropyl alcohol; at 50 ℃; for 0.5h; Inert atmosphere; Microwave irradiation; Molecular sieve;

With hydrogenchloride; In methanol; at 20 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201402884

Reference yield: 97.0%

(R)-N-((R)-1-(furan-2-yl)ethyl)-2-methylpropane-2-sulfinamide → (R)-1-(furan-2-yl)ethanamine (132523-44-5)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.15227/orgsyn.090.0338

Reference yield: 80.0%

(S)-2-methyl-propane-2-sulfinic acid ((R)-1-furan-2-yl-ethyl)-amide (1426421-68-2) → (R)-1-(furan-2-yl)ethanamine (132523-44-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

DOI:10.1021/acsmedchemlett.5b00167

upstream raw materials:

N-((R)-1-Furan-2-yl-ethyl)-acetamide

(Z)-1-(furan-2-yl)ethanone O-benzyloxime

1-(2-furyl)-1-ethanone

(Z)-1-(furan-2-yl)ethanone oxime

Downstream raw materials:

D-Alanine