S,S-α,α'-bis(1,1-diMethylethyl)-[2,2'-Bipyridine]-6,6'-diMethanol

Base Information

Chemical Name:S,S-α,α'-bis(1,1-diMethylethyl)-[2,2'-Bipyridine]-6,6'-diMethanol
CAS No.:131726-65-3
Molecular Formula:C₂₀H₂₈N₂O₂
Molecular Weight:328.455
Hs Code.:

Synonyms:S,S-α,α'-bis(1,1-diMethylethyl)-[2,2'-Bipyridine]-6,6'-diMethanol;(αS,α'S)-α,α'-Bis(tert-butyl)-[2,2'-bipyridine]-6,6'- dimethanol

Suppliers and Price of S,S-α,α'-bis(1,1-diMethylethyl)-[2,2'-Bipyridine]-6,6'-diMethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 14 raw suppliers

Chemical Property of S,S-α,α'-bis(1,1-diMethylethyl)-[2,2'-Bipyridine]-6,6'-diMethanol

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Use Description S,S-α,α'-bis(1,1-dimethylethyl)-[2,2'-bipyridine]-6,6'-dimethanol, also known as S,S-BIPHEMOL, serves various roles in different fields. In the field of coordination chemistry, it acts as a chelating ligand, forming stable complexes with metal ions. These complexes find applications in catalysis, particularly in the synthesis of fine chemicals and pharmaceuticals. In organic chemistry, S,S-BIPHEMOL can be used as a chiral auxiliary, enabling the asymmetric synthesis of compounds with high optical purity. Furthermore, in materials science, S,S-α,α'-bis(1,1-diMethylethyl)-[2,2'-Bipyridine]-6,6'-diMethanol can be utilized in the design and fabrication of novel materials, such as metal-organic frameworks (MOFs) and coordination polymers, which have diverse applications in gas storage, catalysis, and sensing. Its versatility as a ligand and chiral auxiliary makes S,S-α,α'-bis(1,1-dimethylethyl)-[2,2'-bipyridine]-6,6'-dimethanol a valuable molecule with broad significance in the fields of chemistry and materials science.

Technology Process of S,S-α,α'-bis(1,1-diMethylethyl)-[2,2'-Bipyridine]-6,6'-diMethanol

There total 10 articles about S,S-α,α'-bis(1,1-diMethylethyl)-[2,2'-Bipyridine]-6,6'-diMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 127049-52-9
(S)-1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-ol

: 131726-65-3
(S, S)-6,6’-bis(1-hydroxy-2,2-dimethylpropyl)-2,2’-bipyridine

Guidance literature:: With Tetrakis(dimethylamino)ethylen; bis(benzonitrile)palladium(II) dichloride; In N,N-dimethyl-formamide; at 50 ℃; for 10h;
DOI:10.1055/s-2005-869983

Reference yield:

: 127049-48-3
1-(6-bromopyridin-2-yl)-2,2-dimethylpropan-1-one

: 131726-65-3
(S, S)-6,6’-bis(1-hydroxy-2,2-dimethylpropyl)-2,2’-bipyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / formic acid; Et₃N / RuCl[(1S,2S)-N-p-tosyl-1,2-diphenylethanediamine](p-cymene) / 14 h / 20 °C

2: 93 percent / tetrakis(dimethylamino)ethylene / PdCl₂(PhCN)2 / dimethylformamide / 10 h / 50 °C

With formic acid; Tetrakis(dimethylamino)ethylen; triethylamine; bis(benzonitrile)palladium(II) dichloride; RuCl(p-cymene)[N-(p-tosyl)-(1R,2R)-diphenylethylenediamine]; In N,N-dimethyl-formamide;
DOI:10.1055/s-2005-869983

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 131726-65-3
(S, S)-6,6’-bis(1-hydroxy-2,2-dimethylpropyl)-2,2’-bipyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Schlenk technique

1.2: 1 h / -78 °C

1.3: 2 h / 60 °C

2.1: Noyori's catalyst; formic acid; triethylamine / 20 h / 20 °C / Inert atmosphere

3.1: bis(benzonitrile)palladium(II) dichloride; Tetrakis(dimethylamino)ethylen / N,N-dimethyl-formamide / 28 h / 50 °C / Inert atmosphere

With bis(benzonitrile)palladium(II) dichloride; Noyori's catalyst; n-butyllithium; formic acid; Tetrakis(dimethylamino)ethylen; triethylamine; In diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201800452