6-Chloroacetamidotetramethylrhodamine

Base Information

Chemical Name:6-Chloroacetamidotetramethylrhodamine
CAS No.:159435-08-2
Molecular Formula:C₂₆H₂₄ClN₃O₄
Molecular Weight:477.947
Hs Code.:
Mol file:159435-08-2.mol

Synonyms:6-Chloroacetamido-36bis(dimethylamino)spiro[13dihydroisobenzofuran-1,9xanthen]-3-on;6-Chloroacetamidotetramethylrhodamine;(6-Chloroacetamido-36bis(dimethylamino)spiro[13dihydroisobenzofuran-1,9xanthen]-3-one);N-[3',6'-Bis(diMethylaMino)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-yl]-2-chloroacetaMide

Suppliers and Price of 6-Chloroacetamidotetramethylrhodamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6-CHLOROACETAMIDOTETRAMETHYL RHODAMINE 95.00%
5MG
$ 502.99

Total 3 raw suppliers

Chemical Property of 6-Chloroacetamidotetramethylrhodamine

Chemical Property:

PSA：74.60000
LogP:5.21340

Purity/Quality:

99% ^*data from raw suppliers

6-CHLOROACETAMIDOTETRAMETHYL RHODAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Derivative of 6-IATR

Technology Process of 6-Chloroacetamidotetramethylrhodamine

There total 7 articles about 6-Chloroacetamidotetramethylrhodamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5466-84-2
4-nitrophthalic anhydride

: 159435-08-2
6-chloroacetamido-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 3 percent / 2.) conc. H₂SO₄ / 1) toluene, reflux, 6 h; 2) reflux, 8 h

2: H₂ / Pd/C / acetic acid / 5 h / Ambient temperature

3: 1.) pyridine, 2.) aq. NaOH / 1) room temperature, 16 h; 2) methanol, reflux, 1 h

4: 26 percent / trimethylsilyl polyphosphate / dimethylformamide / 4 h / 130 °C

5: 77 percent / aq. HCl / ethanol / 2 h / Heating

6: dimethylformamide / 3 h / 75 °C

With pyridine; hydrogenchloride; sodium hydroxide; trimethylsilylphosphate; sulfuric acid; hydrogen; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 610-27-5
4-nitrophthalic acid

: 159435-08-2
6-chloroacetamido-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / acetic anhydride / 1) 60 deg C, 1 h; 2) reflux, 10 min

2: 3 percent / 2.) conc. H₂SO₄ / 1) toluene, reflux, 6 h; 2) reflux, 8 h

3: H₂ / Pd/C / acetic acid / 5 h / Ambient temperature

4: 1.) pyridine, 2.) aq. NaOH / 1) room temperature, 16 h; 2) methanol, reflux, 1 h

5: 26 percent / trimethylsilyl polyphosphate / dimethylformamide / 4 h / 130 °C

6: 77 percent / aq. HCl / ethanol / 2 h / Heating

7: dimethylformamide / 3 h / 75 °C

With pyridine; hydrogenchloride; sodium hydroxide; trimethylsilylphosphate; sulfuric acid; hydrogen; acetic anhydride; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 159435-02-6
methyl 2-(4'-dimethylamino-2'-hydroxybenzoyl)-4-nitrobenzoate

: 159435-08-2
6-chloroacetamido-3',6'-bis(dimethylamino)spiro<1,3-dihydroisobenzofuran-1,9'-xanthen>-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / acetic acid / 5 h / Ambient temperature

2: 1.) pyridine, 2.) aq. NaOH / 1) room temperature, 16 h; 2) methanol, reflux, 1 h

3: 26 percent / trimethylsilyl polyphosphate / dimethylformamide / 4 h / 130 °C

4: 77 percent / aq. HCl / ethanol / 2 h / Heating

5: dimethylformamide / 3 h / 75 °C

With pyridine; hydrogenchloride; sodium hydroxide; trimethylsilylphosphate; hydrogen; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;