(2S)-Pyrrolidine-2-carbonitrile p-toluene sulfonate

Base Information

Chemical Name:(2S)-Pyrrolidine-2-carbonitrile p-toluene sulfonate
CAS No.:204387-54-2
Molecular Formula:C₅H₈N₂*C₇H₈O₃S
Molecular Weight:268.337
Hs Code.:

Synonyms:(2S)-Pyrrolidine-2-carbonitrile p-toluene sulfonate;(2S)-2-pyrrolidinecarbonitrile 4-methylbenzenesulfonate

Suppliers and Price of (2S)-Pyrrolidine-2-carbonitrile p-toluene sulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 10 raw suppliers

Chemical Property of (2S)-Pyrrolidine-2-carbonitrile p-toluene sulfonate

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (2S)-Pyrrolidine-2-carbonitrile p-toluene sulfonate

There total 4 articles about (2S)-Pyrrolidine-2-carbonitrile p-toluene sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 104-15-4
toluene-4-sulfonic acid

: 228244-04-0
tert-butyl (2S)-2-cyanopyrrolidine-1-carboxylate

: 204387-54-2
(2S)-pyrrolidine-2-carbonitrile 4-methylbenzene-1-sulfonic acid

Guidance literature:: In water; acetonitrile; for 24h;
DOI:10.1016/j.bmc.2013.09.048

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 204387-54-2
(2S)-pyrrolidine-2-carbonitrile 4-methylbenzene-1-sulfonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 24 h / 20 °C

2: ammonium bicarbonate; pyridine / 1,4-dioxane / 6 h / 20 °C

3: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 1 h / 20 °C

4: water; acetonitrile / 24 h

With pyridine; 1,3,5-trichloro-2,4,6-triazine; sodium hydrogencarbonate; ammonium bicarbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.09.048

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 204387-54-2
(2S)-pyrrolidine-2-carbonitrile 4-methylbenzene-1-sulfonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium bicarbonate; pyridine / 1,4-dioxane / 6 h / 20 °C

2: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 1 h / 20 °C

3: water; acetonitrile / 24 h

With pyridine; 1,3,5-trichloro-2,4,6-triazine; ammonium bicarbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.09.048