1-(thiophen-2-yl)cyclopentanecarboxylic acid

Base Information

• Chemical Name: 1-(thiophen-2-yl)cyclopentanecarboxylic acid
• CAS No.: 202737-46-0
• Molecular Formula: C10H12O2S
• Molecular Weight: 196.27
• Mol file: 202737-46-0.mol

Synonyms:1-(thiophen-2-yl)cyclopentanecarboxylic acid;1-(2-Thienyl)cyclopentanecarboxylic acid

Chemical Property of 1-(thiophen-2-yl)cyclopentanecarboxylic acid

Chemical Property:

• PSA: 65.54000
• LogP: 2.64450

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(2-Thienyl)cyclopentanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(thiophen-2-yl)cyclopentanecarboxylic acid

There total 3 articles about 1-(thiophen-2-yl)cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(thiophen-2-yl)cyclopentanecarbonitrile (59397-14-7) → 1-(2-thienyl)cyclopentacarboxylic acid (202737-46-0)

Guidance literature:

With hydrogen bromide; acetic acid;

DOI:10.1021/ja01173a044

Reference yield:

2-cyanomethylthiophene (20893-30-5) → 1-(2-thienyl)cyclopentacarboxylic acid (202737-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium amide; ammonia; diethyl ether / -50 °C / Erwaermen des vom Ammoniak befreiten, mit Toluol versetzten Reaktionsgemisches auf Siedetemperatur

2: aqueous hydrobromic acid; acetic acid

With diethyl ether; ammonia; hydrogen bromide; sodium amide; acetic acid;

DOI:10.1021/ja01173a044

Reference yield:

→ 1-(2-thienyl)cyclopentacarboxylic acid (202737-46-0)

Guidance literature:

upstream raw materials:

1-(thiophen-2-yl)cyclopentanecarbonitrile

2-cyanomethylthiophene

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