2-CHLORO-N-(2-CHLORO-4,6-DIMETHYLPHENYL)ACETAMIDE

Base Information

• Chemical Name: 2-CHLORO-N-(2-CHLORO-4,6-DIMETHYLPHENYL)ACETAMIDE
• CAS No.: 444325-43-3
• Molecular Formula: C₁₀H₁₁Cl₂NO
• Molecular Weight: 232.109
• Mol file: 444325-43-3.mol

Synonyms:AKOS BBS-00004028;2-CHLORO-N-(2-CHLORO-4,6-DIMETHYLPHENYL)ACETAMIDE

Chemical Property of 2-CHLORO-N-(2-CHLORO-4,6-DIMETHYLPHENYL)ACETAMIDE

Chemical Property:

• PSA: 29.10000
• LogP: 3.20710

Purity/Quality:

99% ^*data from raw suppliers

2-CHLORO-N-(2-CHLORO-4,6-DIMETHYL-PHENYL)-ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-CHLORO-N-(2-CHLORO-4,6-DIMETHYLPHENYL)ACETAMIDE

There total 1 articles about 2-CHLORO-N-(2-CHLORO-4,6-DIMETHYLPHENYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4,6-dimethylaniline (63133-82-4) + Chloroacetic anhydride (541-88-8) → 2-chloro-N-(2-chloro-4,6-dimethyl-phenyl)-acetamide (444325-43-3)

Guidance literature:

In 1,2-dichloro-ethane; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2005.05.117

Reference yield:

2-chloro-N-(2-chloro-4,6-dimethyl-phenyl)-acetamide (444325-43-3) → 2-azido-N-(2-chloro-4,6-dimethyl-phenyl)-acetamide (444325-44-4)

Guidance literature:

With sodium azide; potassium iodide; In N,N-dimethyl-formamide; at 50 ℃; for 4h;

DOI:10.1016/j.bmcl.2005.05.117

Reference yield:

2-chloro-N-(2-chloro-4,6-dimethyl-phenyl)-acetamide (444325-43-3) → 7-(2-chloro-4,6-dimethyl-phenyl)-2-ethyl-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid cyclopropylmethyl-(2,2,2-trifluoro-ethyl)-amide

Guidance literature:

Multi-step reaction with 6 steps

1: NaN₃; KI / dimethylformamide / 4 h / 50 °C

2: BH₃ / tetrahydrofuran / 14 h / Heating

3: ethanol / 0.67 h / Heating

4: acetone / 12 h / Heating

5: EtCOONa / 8 h / 170 °C

6: AlMe₃ / toluene / 14 h / 80 °C

With sodium azide; borane; sodium proprionate; trimethylaluminum; potassium iodide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1016/j.bmcl.2005.05.117

upstream raw materials:

2-chloro-4,6-dimethylaniline

Chloroacetic anhydride

Downstream raw materials:

2-azido-N-(2-chloro-4,6-dimethyl-phenyl)-acetamide

N¹-(2-chloro-4,6-dimethyl-phenyl)-ethane-1,2-diamine

1-(2-chloro-4,6-dimethyl-phenyl)-imidazolidin-2-ylideneamine

7-(2-chloro-4,6-dimethyl-phenyl)-2-ethyl-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid ethyl ester