5-Bromo-6-phenyltetrahydro-2H-pyran-2-one

Base Information

Chemical Name:5-Bromo-6-phenyltetrahydro-2H-pyran-2-one
CAS No.:54966-45-9
Molecular Formula:C₁₁H₁₁BrO₂
Molecular Weight:255.111
Hs Code.:
Mol file:54966-45-9.mol

Synonyms:5-Bromo-6-phenyltetrahydro-2H-pyran-2-one;5-Bromotetrahydro-6-phenyl-2H-pyran-2-one

Suppliers and Price of 5-Bromo-6-phenyltetrahydro-2H-pyran-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Bromo-6-phenyltetrahydro-2H-pyran-2-one

Chemical Property:

Boiling Point:396.6±42.0 °C(Predicted)
Density:1.478±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-Bromo-6-phenyltetrahydro-2H-pyran-2-one

There total 8 articles about 5-Bromo-6-phenyltetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 28525-69-1
(4E)-5-phenyl-4-pentenoic acid

: 54966-45-9,100238-91-3,130505-96-3
(5S*,6R*)-5-bromo-6-phenyltetrahydro-2H-pyran-2-one

Guidance literature:: With N-Bromosuccinimide; di(endo-3-camphoryl) diselenide; In acetonitrile; at -35 ℃; for 2h; Molecular sieve;
DOI:10.1021/acs.joc.9b01294

Reference yield: 86.0%

: 17920-83-1,73850-25-6,28525-69-1
5-phenyl-4-pentenoic acid

: 54966-45-9,100238-91-3,130505-96-3
(5S*,6R*)-5-bromo-6-phenyltetrahydro-2H-pyran-2-one

Guidance literature:: With N-Bromosuccinimide; 1,1,1,3',3',3'-hexafluoro-propanol; In dichloromethane; at -40 ℃; for 1h; Sealed tube;
DOI:10.1002/anie.202010846

Reference yield:

: 4407-36-7
(2E)-3-phenyl-2-propen-1-ol

: 54966-45-9,100238-91-3,130505-96-3
(5S*,6R*)-5-bromo-6-phenyltetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus tribromide / diethyl ether / 0 °C / Inert atmosphere; Darkness

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 20 h / 0 - 20 °C

3.1: potassium hydroxide / methanol; water / 21 h / 110 °C

3.2: 170 - 190 °C

4.1: (Z)-1-benzylcyclooct-1-ene / dichloromethane / 0.5 h / -30 °C

4.2: 12 h / -30 °C

With (Z)-1-benzylcyclooct-1-ene; phosphorus tribromide; sodium hydride; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; mineral oil;
DOI:10.1002/anie.201808320