1,1,2-Cyclopropanetricarboxylic acid trimethyl ester

Base Information

• Chemical Name: 1,1,2-Cyclopropanetricarboxylic acid trimethyl ester
• CAS No.: 22650-26-6
• Molecular Formula: C9H12O6
• Molecular Weight: 216.191
• Hs Code.: 2917209090
• Mol file: 22650-26-6.mol

Synonyms:1,1,2-Cyclopropanetricarboxylic acid trimethyl ester

Chemical Property of 1,1,2-Cyclopropanetricarboxylic acid trimethyl ester

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Boiling Point: 272.7°C at 760 mmHg
• Flash Point: 115.8°C
• PSA: 78.90000
• Density: 1.314g/cm³
• LogP: -0.48830

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1,2-Cyclopropanetricarboxylic acid trimethyl ester

There total 8 articles about 1,1,2-Cyclopropanetricarboxylic acid trimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + dimethyl 2-bromomalonate (868-26-8) → Tetramethyl ethylenetetracarboxylate (1733-15-9) + trimethyl cyclopropane-1,1,2-tricarboxylate (22650-26-6)

Guidance literature:

With potassium fluoride on basic alumina; at 70 ℃; for 15h; addition at room temperature; further reagent: KF-Alumine-Si(OMe)4;

DOI:10.1016/S0040-4039(00)98602-7

Reference yield:

dimethyl 2-phenyl-1,1-cyclopropanedicarboxylate (3709-20-4) + methyl diazoacetate (6832-16-2) → methyl (2Z)-3-phenylprop-2-enoate (19713-73-6,1754-62-7) + trimethyl cyclopropane-1,1,2-tricarboxylate (22650-26-6) + Methyl cinnamate (103-26-4,1754-62-7)

Guidance literature:

With tin(IV) chloride; In dichloromethane; at 25 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1007/s11172-018-2069-8

Reference yield:

dimethyl 2-phenyl-1,1-cyclopropanedicarboxylate (3709-20-4) + methyl diazoacetate (6832-16-2) → methyl (2Z)-3-phenylprop-2-enoate (19713-73-6,1754-62-7) + trimethyl cyclopropane-1,1,2-tricarboxylate (22650-26-6) + dimethyl 2-(2-methoxy-2-oxoethyl)-2-phenylcyclopropane-1,1-dicarboxylate + Methyl cinnamate (103-26-4,1754-62-7)

Guidance literature:

With tin(IV) chloride; In dichloromethane; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1007/s11172-018-2069-8

upstream raw materials:

acrylic acid methyl ester

dimethyl 2-bromomalonate

methyl diazoacetate

dimethyl 2-(thiophen-2-yl)cyclopropane-1,1-dicarboxylate

Downstream raw materials:

cyclopropane-1,1,2-tricarboxylic acid

Refernces

• 1、 Joucla, M.,Brun, J. Le. "REACTIONS DE CYCLISATIONS INDUITES PAR DES FLUORURES ALCALINS : FORMATION DE CYCLOPROPANES.". . p. 3001 - 3004. Retrieved 2007/10/02.