tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate
• CAS No.: 1042428-82-9
• Molecular Formula: C₁₄H₁₇BrFNO₃
• Molecular Weight: 346.196
• Mol file: 1042428-82-9.mol

Synonyms:tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate

Chemical Property of tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate

There total 2 articles about tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-difluorobromobenzene (348-57-2) + tert-butyl 3-hydroxyazetidine-1-carboxylate (141699-55-0) → tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate (1042428-82-9)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 50 ℃; for 1h;

Reference yield:

tert-butyl 3-hydroxyazetidine-1-carboxylate (141699-55-0) + 2-bromo-5-fluorophenol (147460-41-1) → tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate (1042428-82-9)

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 75 ℃; for 16h;

DOI:10.1016/j.bmcl.2010.10.107

Reference yield:

tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate (1042428-82-9) → 3-(2-bromo-5-fluorophenoxy)azetidine hydrochloride salt (1042428-83-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 18h;

upstream raw materials:

2,4-difluorobromobenzene

tert-butyl 3-hydroxyazetidine-1-carboxylate

2-bromo-5-fluorophenol

Downstream raw materials:

3-(2-bromo-5-fluorophenoxy)azetidine hydrochloride salt

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