BOC-L-LEUCINE THIOAMIDE

Base Information

• Chemical Name: BOC-L-LEUCINE THIOAMIDE
• CAS No.: 99701-60-7
• Molecular Formula: C₁₁H₂₂N₂O₂S
• Molecular Weight: 246.374
• Hs Code.: 2930909090
• Mol file: 99701-60-7.mol

Synonyms:BOC-L-LEUCINE THIOAMIDE;N-TERT-BUTOXYCARBONYL-L-LEUCINE THIOAMIDE

Chemical Property of BOC-L-LEUCINE THIOAMIDE

Chemical Property:

• PSA: 96.44000
• Density: 1.062±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 3.30310

Purity/Quality:

BOC-L-LEUCINE THIOAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-L-LEUCINE THIOAMIDE

There total 6 articles about BOC-L-LEUCINE THIOAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-tert-butoxycarbonyl-(L)-leucinamide (70533-96-9) → tert-butyl (S)-(1-amino-4-methyl-1-thioxopentan-2-yl)carbamate (99701-60-7)

Guidance literature:

With Lawessons reagent; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1002/anie.201612103

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (S)-(1-amino-4-methyl-1-thioxopentan-2-yl)carbamate (99701-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Et₃N / CH₂Cl₂ / 3 h

2: 73 percent / 2,4-bis(4-phenoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide (PTPS) / tetrahydrofuran / 6 h / Ambient temperature

With 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00215a040

Reference yield:

(2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) → tert-butyl (S)-(1-amino-4-methyl-1-thioxopentan-2-yl)carbamate (99701-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Et₃N / CH₂Cl₂ / 3 h

2: 73 percent / 2,4-bis(4-phenoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide (PTPS) / tetrahydrofuran / 6 h / Ambient temperature

With 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00215a040

upstream raw materials:

N-tert-butoxycarbonyl-(L)-leucinamide

di-tert-butyl dicarbonate

(2S)-amino-4-methylpentanamide hydrochloride

N-tert-butoxycarbonyl-L-leucine methyl ester

Downstream raw materials:

C₃₆H₅₅N₅O₇S

C₃₀H₄₃N₅O₄S

C₃₈H₅₉N₅O₇S

C₃₆H₅₅N₅O₇S