2',3',5'-trideoxyadenosine

Base Information

• Chemical Name: 2',3',5'-trideoxyadenosine
• CAS No.: 6612-70-0
• Molecular Formula: C10H13N5O
• Molecular Weight: 219.2431
• Mol file: 6612-70-0.mol

Synonyms:Adenosine,2',3',5'-trideoxy;2',3',5'-Trideoxyadenosin;2',3',5'-Trideoxyadenosine;2',3',5'-Tridesoxy-adenosin;

Chemical Property of 2',3',5'-trideoxyadenosine

Chemical Property:

• Vapor Pressure: 9.28E-09mmHg at 25°C
• Boiling Point: 463.2°Cat760mmHg
• Flash Point: 233.9°C
• PSA: 78.85000
• Density: 1.61g/cm³
• LogP: 1.68720

Purity/Quality:

99%, ^*data from raw suppliers

9-(Tetrahydro-5-methyl-2-furyl)adenine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 9-(Tetrahydro-5-methyl-2-furyl)adenine (Didanosine EP Impurity H) is an impurity of Didanosine (D440950), which used as an antiviral agent. Classed as an anti-retroviral drug used in the treatment of HIV in ART therapy, it also may increase acetaminophen related hepatotoxicity by enhancing mitochrondrial dysfunction (2).

Technology Process of 2',3',5'-trideoxyadenosine

There total 3 articles about 2',3',5'-trideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2',3',5'-Trideoxyadenosin (6612-70-0,93780-27-9)

Guidance literature:

6-Amino-9-(3',5'-di-S-ethyl-3',5'-dithio-2',3',5'-trideoxy-β-D-threopentofuranosyl)purin (XV), Raney-Ni, Methylcellosolve, EtOH;

DOI:10.1021/bi00865a029

Reference yield:

→ 9-(5-methyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine (6612-70-0,93780-27-9)

Guidance literature:

10b,H2,Pd/C,NaHCO3;

DOI:10.1021/ja00441a054

Reference yield:

→ 9-<5-Methyl-tetrahydrofuryl-(2)>-6-amino-purin (6612-70-0,93780-27-9)

Guidance literature:

9-<5-Methyl-tetrahydrofuryl-(2)>-6-chlor-purin (F.73-74grad), NH3;

DOI:10.1021/jm00341a002

Refernces