N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine

Base Information

• Chemical Name: N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine
• CAS No.: 1346546-69-7
• Molecular Formula: C₁₉H₁₇N₃O₂S₂
• Molecular Weight: 383.495
• Mol file: 1346546-69-7.mol

Synonyms:N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine

Chemical Property of N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine

Chemical Property:

• Boiling Point: 625.7±55.0 °C(Predicted)
• PKA: 5.53±0.49(Predicted)
• PSA: 108.57000
• Density: 1.395±0.06 g/cm3(Predicted)
• LogP: 5.92400
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Soluble in DMSO (up to at least 25 mg/ml)

Purity/Quality:

99%+, ^*data from raw suppliers

GSK''872 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: GSK 872 (CAS 1346546-69-7) is a potent (IC50 = 1.8nM domain binding; IC50 = 1.3 nM kinase activity) and selective inhibitor of receptor interacting protein 3 (RIP3).1 It is able to prevent necroptosis, virus-induced necrosis, and TLR3-induced necrosis.1,2 GSK872 can induce Caspase8-mediated apoptosis at higher concentrations (e.g.3 μM).2
• Uses: GSK''872 is a potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC50 = 1.3 nM). Exhibits >1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro. Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 μM).

Technology Process of N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine

There total 1 articles about N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ GSK'872 (1346546-69-7)

Guidance literature:

With sulfuric acid; In ethanol; at 80 ℃; for 18h;

Refernces