N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine

Base Information

Chemical Name:N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine
CAS No.:1346546-69-7
Molecular Formula:C₁₉H₁₇N₃O₂S₂
Molecular Weight:383.495
Hs Code.:
Mol file:1346546-69-7.mol

Synonyms:N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine

Suppliers and Price of N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
GSK''872
1mg
$ 55.00

Tocris
GSK'872 ≥98%(HPLC)
10
$ 169.00

Tocris
GSK'872 ≥98%(HPLC)
50
$ 710.00

DC Chemicals
GSK-872 >98%
100 mg
$ 500.00

Crysdot
GSK'872 95%
25mg
$ 257.00

Crysdot
GSK'872 95%
100mg
$ 764.00

Crysdot
GSK'872 95%
50mg
$ 491.00

Crysdot
GSK'872 95%
10mg
$ 144.00

Crysdot
GSK'872 95%
2mg
$ 47.00

Crysdot
GSK'872 95%
5mg
$ 85.00

Total 14 raw suppliers

Chemical Property of N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine

Chemical Property:

Boiling Point:625.7±55.0 °C(Predicted)
PKA:5.53±0.49(Predicted)
PSA：108.57000
Density:1.395±0.06 g/cm3(Predicted)
LogP:5.92400
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
Solubility.:Soluble in DMSO (up to at least 25 mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

GSK''872 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description GSK 872 (CAS 1346546-69-7) is a potent (IC50 = 1.8nM domain binding; IC50 = 1.3 nM kinase activity) and selective inhibitor of receptor interacting protein 3 (RIP3).1 It is able to prevent necroptosis, virus-induced necrosis, and TLR3-induced necrosis.1,2 GSK872 can induce Caspase8-mediated apoptosis at higher concentrations (e.g.3 μM).2
Uses GSK''872 is a potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC50 = 1.3 nM). Exhibits >1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro. Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 μM).

Technology Process of N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine

There total 1 articles about N-5-benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-Quinolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: