3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-iodophenoxy)methyl]-1-propanol

Base Information

Chemical Name:3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-iodophenoxy)methyl]-1-propanol
CAS No.:1263188-77-7
Molecular Formula:C₁₆H₂₇IO₃Si
Molecular Weight:422.379
Hs Code.:

Synonyms:3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-iodophenoxy)methyl]-1-propanol

Suppliers and Price of 3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-iodophenoxy)methyl]-1-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-iodophenoxy)methyl]-1-propanol

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

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Technology Process of 3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-iodophenoxy)methyl]-1-propanol

There total 3 articles about 3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-iodophenoxy)methyl]-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1263188-76-6
tert-butyl({2-[(4-iodophenoxy)methyl]-2-propenyl}oxy)dimethylsilane

: 1263188-77-7
3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-iodophenoxy)methyl]-1-propanol

Guidance literature:: tert-butyl({2-[(4-iodophenoxy)methyl]-2-propenyl}oxy)dimethylsilane; With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0 - 20 ℃; for 17h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 116700-73-3
2-(tert-butyl-dimethyl-silanyloxymethyl)-prop-2-en-1-ol

: 1263188-77-7
3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-iodophenoxy)methyl]-1-propanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 6 h / 5 °C

2.1: potassium carbonate / acetone / 50 °C

3.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 20 °C

3.2: 3 h / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; iodine; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1016/j.bmcl.2015.07.084

Reference yield:

: 791131-36-7
tert-butyl((2-(iodomethyl)allyl)oxy)dimethylsilane

: 1263188-77-7
3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-iodophenoxy)methyl]-1-propanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 50 °C

2.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 3 h / 0 - 20 °C

With sodium tetrahydroborate; iodine; potassium carbonate; In tetrahydrofuran; acetone;
DOI:10.1016/j.bmcl.2015.07.084