CalpinactaM

Base Information

• Chemical Name: CalpinactaM
• CAS No.: 1205538-83-5
• Molecular Formula: C38H57N9O8
• Molecular Weight: 767.926
• Mol file: 1205538-83-5.mol

Synonyms:CalpinactaM;D-Phenylalanyl-L-leucyl-L-histidyl-D-alpha-glutamyl-N-[(3S)-hexahydro-2-oxo-1H-azepin-3-yl]-D-alloisoleucinamide;FKI-4905

Chemical Property of CalpinactaM

Chemical Property:

• PSA: 266.60000
• LogP: 3.18690

Purity/Quality:

98% ^*data from raw suppliers

Calpinactam ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CalpinactaM

There total 2 articles about CalpinactaM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

calpinactam + 2-aminocaprolactam (21568-87-6) → C38H57N9O8 (1205538-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

2: trifluoroacetic acid; chlorotriisopropylsilane / water / 1 h / 20 °C

With chlorotriisopropylsilane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.09.069

Reference yield:

C43H65N9O10 → calpinactam (1205538-83-5)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 1.5h;

DOI:10.1021/ol902553z

upstream raw materials:

2-aminocaprolactam

Refernces

• 1、 Koyama, Nobuhiro,Kojima, Shigenobu,Fukuda, Takeo,Nagamitsu, Tohru,Yasuhara, Tadashi,Omura, Satoshi,Tomoda, Hiroshi. "Structure and total synthesis of fungal calpinactam, a new antimycobacterial agent". supporting information; experimental part. p. 432 - 435. Retrieved 2010/04/24.