N-[(2S)-2-(acetylamino)propanoyl]-1-{(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-[(2-phenylethyl)amino]hexan-3-yl}-L-prolinamide

Base Information

Chemical Name:N-[(2S)-2-(acetylamino)propanoyl]-1-{(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-[(2-phenylethyl)amino]hexan-3-yl}-L-prolinamide
CAS No.:119720-81-9
Molecular Formula:C25H34 F2 N4 O5
Molecular Weight:508.5581
Hs Code.:
Mol file:119720-81-9.mol

Synonyms:L-Prolinamide,N-acetyl-L-alanyl-N-[3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-[(2-phenylethyl)amino]butyl]-,(S)-; L 708286

Suppliers and Price of N-[(2S)-2-(acetylamino)propanoyl]-1-{(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-[(2-phenylethyl)amino]hexan-3-yl}-L-prolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(2S)-2-(acetylamino)propanoyl]-1-{(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-[(2-phenylethyl)amino]hexan-3-yl}-L-prolinamide

Chemical Property:

Vapor Pressure:8.45E-21mmHg at 25°C
Boiling Point:723.7°Cat760mmHg
Flash Point:391.5°C
Density:1.223g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[(2S)-2-(acetylamino)propanoyl]-1-{(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-[(2-phenylethyl)amino]hexan-3-yl}-L-prolinamide

There total 8 articles about N-[(2S)-2-(acetylamino)propanoyl]-1-{(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-[(2-phenylethyl)amino]hexan-3-yl}-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 119720-82-0
N-Acetyl-L-alanyl-N-<3,3-difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-L-prolinamide

: 119720-81-9
(S)-N-Acetyl-L-alanyl-N-<3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-<(2-phenylethyl)amino>butyl>-L-prolinamide

Guidance literature:: With Dess-Martin periodane; trifluoroacetic acid; In dichloromethane; Ambient temperature;
DOI:10.1021/ja00191a039

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 119720-81-9
(S)-N-Acetyl-L-alanyl-N-<3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-<(2-phenylethyl)amino>butyl>-L-prolinamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -20 deg C, 15 min; 2.) -40 deg C -> room temp.

2: 100 percent / 1.) oxalyl chloride, DMSO; 2.) diisopropylethylamine / CH₂Cl₂ / 1.) -25 deg C, 1 h; 2.) -40 deg C -> room temp.

3: 39.2 percent / Zn / tetrahydrofuran / 4 h / Heating

4: 86.2 percent / ethanol / 1.) 4 h, reflux; 2.) room temp., 48 h,

5: 86.6 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr

6: 41 percent / 1-ethyl-<3-(3-dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate / CH₂Cl₂ / 24 h / Ambient temperature

7: 48 percent / Dess-Martin periodinane, CF₃COOH / CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; oxalyl dichloride; hydrogen; Dess-Martin periodane; dimethyl sulfoxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja00191a039

Reference yield:

: 109522-66-9
*,R^*)>-2-<<<1-Formyl-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

: 119720-81-9
(S)-N-Acetyl-L-alanyl-N-<3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-<(2-phenylethyl)amino>butyl>-L-prolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: 39.2 percent / Zn / tetrahydrofuran / 4 h / Heating

2: 86.2 percent / ethanol / 1.) 4 h, reflux; 2.) room temp., 48 h,

3: 86.6 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr

4: 41 percent / 1-ethyl-<3-(3-dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole hydrate / CH₂Cl₂ / 24 h / Ambient temperature

5: 48 percent / Dess-Martin periodinane, CF₃COOH / CH₂Cl₂ / Ambient temperature

With hydrogen; Dess-Martin periodane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja00191a039