N-(4-amino-2-methylphenyl)benzamide

Base Information

• Chemical Name: N-(4-amino-2-methylphenyl)benzamide
• CAS No.: 104478-99-1
• Molecular Formula: C14H14N2O
• Molecular Weight: 226.278
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID80390552
• Wikidata: Q82187401
• Pharos Ligand ID: XXSAQMS5ZZVF
• ChEMBL ID: CHEMBL1470888
• Mol file: 104478-99-1.mol

Synonyms:N-(4-amino-2-methylphenyl)benzamide;104478-99-1;ASISCHEM U63903;SMR000019296;Oprea1_757102;MLS000084950;SCHEMBL1548172;CHEMBL1470888;DTXSID80390552;NBDOSEUNJLCDLN-UHFFFAOYSA-N;HMS2380C17;N-benzoyl 2-methyl-4-aminoaniline;BBL000213;MFCD01145119;STK099304;AKOS000110992;N-(4-amino-2-methylphenyl)-benzamide;N-(4-Amino-2-methyl-phenyl)-benzamide;VS-00494;4-BROMOBENZOYLFORMIC ACID ETHYL ESTER;BB 0245988;CS-0313756;FT-0744050;SR-01000413840;SR-01000413840-1

Chemical Property of N-(4-amino-2-methylphenyl)benzamide

Chemical Property:

• Vapor Pressure: 0.000379mmHg at 25°C
• Boiling Point: 317.7°C at 760 mmHg
• Flash Point: 145.9°C
• PSA: 55.12000
• Density: 1.21g/cm³
• LogP: 3.48370
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 226.110613074
• Heavy Atom Count: 17
• Complexity: 261

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-Amino-2-methylphenyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)N)NC(=O)C2=CC=CC=C2

Technology Process of N-(4-amino-2-methylphenyl)benzamide

There total 7 articles about N-(4-amino-2-methylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-(2-methyl-4-nitrophenyl)benzamide (104478-92-4) → N-(2-methyl-4-aminophenyl)benzamide (104478-99-1)

Guidance literature:

With tin(II) chloride dihdyrate; In ethyl acetate; at 70 ℃; for 19h;

Reference yield: 97.0%

tin(II)chloride dihydrate + N-(2-methyl-4-nitrophenyl)benzamide (104478-92-4) → N-(2-methyl-4-aminophenyl)benzamide (104478-99-1)

Guidance literature:

In ethyl acetate;

Reference yield:

2-methyl-4-nitro-benzenamine (99-52-5) → N-(2-methyl-4-aminophenyl)benzamide (104478-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: cyclohexene / 10 percent Pd/C / propan-2-ol

With cyclohexene; palladium on activated charcoal; In pyridine; isopropyl alcohol;

upstream raw materials:

N-(2-methyl-4-nitrophenyl)benzamide

benzoyl chloride

2-methyl-4-nitro-benzenamine

benzoic acid

Downstream raw materials:

C₁₉H₂₀N₄O₅

N-[4-({[(5-chloro(2-thienyl))sulfonyl]amino}carbonylamino)-2-methylphenyl]benzamide