BenzenaMine, 4-[(2-chloro-4-pyridinyl)oxy]-2,5-difluoro-

Base Information

• Chemical Name: BenzenaMine, 4-[(2-chloro-4-pyridinyl)oxy]-2,5-difluoro-
• CAS No.: 1225278-65-8
• Molecular Formula: C11H7ClF2N2O
• Molecular Weight: 256.639
• Hs Code.: 2933399990
• Mol file: 1225278-65-8.mol

Synonyms:BenzenaMine, 4-[(2-chloro-4-pyridinyl)oxy]-2,5-difluoro-;4-(2-chloropyridin-4-yloxy)-2,5-difluoroaniline

Chemical Property of BenzenaMine, 4-[(2-chloro-4-pyridinyl)oxy]-2,5-difluoro-

Chemical Property:

• PSA: 48.14000
• LogP: 3.96890

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-[(2-Chloro-4-pyridinyl)oxy]-2,5-difluorobenzenamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BenzenaMine, 4-[(2-chloro-4-pyridinyl)oxy]-2,5-difluoro-

There total 3 articles about BenzenaMine, 4-[(2-chloro-4-pyridinyl)oxy]-2,5-difluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-4-(2 ,5-difluoro-4-nitrophenoxy)pyridine (1225278-64-7) → 4-((2-chloropyridin-4-yl)oxy)-2,5-difluoroaniline (1225278-65-8)

Guidance literature:

With ammonium chloride; zinc; In tetrahydrofuran; methanol; at 20 ℃; for 2h; Product distribution / selectivity;

Reference yield:

1,2,4-trifluoro-5-nitrobenzene (2105-61-5) → 4-((2-chloropyridin-4-yl)oxy)-2,5-difluoroaniline (1225278-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / Cooling with ice; Inert atmosphere

1.2: 18 h / 20 °C

2.1: zinc; ammonium chloride / methanol / 1.5 h / 20 °C / Cooling with ice

With sodium hydride; ammonium chloride; zinc; In methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-chloropyridin-4-ol (17368-12-6) → 4-((2-chloropyridin-4-yl)oxy)-2,5-difluoroaniline (1225278-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / Cooling with ice; Inert atmosphere

1.2: 18 h / 20 °C

2.1: zinc; ammonium chloride / methanol / 1.5 h / 20 °C / Cooling with ice

With sodium hydride; ammonium chloride; zinc; In methanol; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

2-chloro-4-(2 ,5-difluoro-4-nitrophenoxy)pyridine

1,2,4-trifluoro-5-nitrobenzene

2-chloropyridin-4-ol

Downstream raw materials:

N-(4-(2-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

N-(4-(2-(1,5-dimethyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

4-(2-(1,5-dimethyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorobenzenamine

4-(2-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorobenzenamine

Refernces

• 1、 -. "PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES". Paragraph 0101. . Retrieved 2014/09/29.
• 2、 -. "PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES". Paragraph 00172. . Retrieved 2013/06/06.