Technology Process of BenzaMide, 3-chloro-N-[(1S)-1-[[4-(2-chloroacetyl)phenyl]Methyl]-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-4-(1-Methylethoxy)-
There total 9 articles about BenzaMide, 3-chloro-N-[(1S)-1-[[4-(2-chloroacetyl)phenyl]Methyl]-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-4-(1-Methylethoxy)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C
1.2: 2 h / 60 °C
2.1: aluminum (III) chloride / 22 h / -5 °C
2.2: 35 - 50 °C
2.3: 18 h / 65 °C
3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C
With
aluminum (III) chloride; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
methanol; toluene; acetonitrile;
1.1: Mitsunobu reaction / 2.1: Friedel Crafts acylation;
DOI:10.1021/op100186c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ethyl acetate / 1.5 h
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / methanol; toluene / 42 - 60 °C
2.2: 2 h / 60 °C
3.1: aluminum (III) chloride / 22 h / -5 °C
3.2: 35 - 50 °C
3.3: 18 h / 65 °C
4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C
With
aluminum (III) chloride; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
methanol; ethyl acetate; toluene; acetonitrile;
2.1: Mitsunobu reaction / 3.1: Friedel Crafts acylation;
DOI:10.1021/op100186c
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydroxide / dimethyl sulfoxide / 1 h / 50 °C
1.2: 50 °C
2.1: water; potassium hydroxide / dimethyl sulfoxide / 80 - 85 °C
2.2: 50 - 60 °C
3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 22 °C
4.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 45 °C
5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 - 8 °C
With
N-chloro-succinimide; oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium hydroxide;
In
dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/op100186c
